DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	508	Identity:	128/508 - (25%)
Similarity:	221/508 - (43%)	Gaps:	46/508 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGS---FPNMIWPRQHFTMDMRDIYMHYRNTHS 70
            :||.|..:|.:...:...:::.|:..|..||..|:   :...:|   :|..:..:.|      ..
Human    15 VATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLW---NFDRECNEKY------GE 70

  Fly    71 YVGCYLLRAPKLLVLEPRLVYEIYV-SAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWRHQR 134
            ..|.|..:.|.|::::|.::..:.| ..:|.|.|......:...|..|     ...|.|||:..|
Human    71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSAL-----SFAEDEEWKRIR 130

  Fly   135 AVFSTLLTNGRIRTTHAIMQRVCLD-LCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGIQAR 198
            .:.|...|:.:.:....|:.: |.| |.:.:..::...|.::..|....:|.:.:...:.|:...
Human   131 TLLSPAFTSVKFKEMVPIISQ-CGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLD 194

  Fly   199 TFTDNPLPVVRQNHEMSAENRGLAIAGAVHGLFPNLP---RWLRPKVFPRSHDRFYGQMISEALR 260
            :. :||.....:|.:...:...|.....:..|||.|.   ..|...:||:....|....|.....
Human   195 SL-NNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKE 258

  Fly   261 LR-RSKHQERNDFINHLLEMQRELD------LSEEDMASHAMTFMFDGLDTTSNSIAHCLLLLGR 318
            .| :.|.:.|.||...:::.|...:      ||:.::.:.::..:|...||||.::...:..|..
Human   259 SRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELAT 323

  Fly   319 NPDCQRRLYEELQLVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKEYELRGSHH 383
            :||.|::|.||:..|.|.......|||:.:.||....||:||::|.....::.|.|:.|:.|
Human   324 HPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEING--- 385

  Fly   384 SEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNGPRQCVGMR 448
               :.:..|..|||||||||:||..:.||:.|.||.......|:......::.||.|||.|:|||
Human   386 ---VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMR 447

  Fly   449 LGLAMAKAALAAIVQRFEVVVSPRTLNGTELDPL--------IFVGVH-KGGI 492
            ..|...|.|:...:|.|.......|....:||.|        |.:.|| :.||
Human   448 FALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGI 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	119/474 (25%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	119/476 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820