DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	493	Identity:	136/493 - (27%)
Similarity:	219/493 - (44%)	Gaps:	76/493 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYRNTHSYVG 73
            :.|.|...|.:...:.|.:::.|:..|:.|||||:..|.:.....|..|.      |:......|
Mouse    15 LVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGNIINYLDGMWKFDDDC------YKKYGKIWG 73

  Fly    74 CYLLRAPKLLVLEPRLVYEIYV-SAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWRHQRAVF 137
            .|....|.|.:::|.::..:.| ..:|.|.|......|...|..:.     :.|.|||:..|.:.
Mouse    74 FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRPFGPVGFLKKSIT-----ISEDEEWKRLRTLL 133

  Fly   138 STLLTNGRIRTTHAIMQRVCLDLCQF--IAIKSA----------------GGKDLDCIDLGLRFT 184
            |...|:.:::....||:       |:  |.:::.                |...:|.|      |
Mouse   134 SPTFTSSKLKEMFPIMR-------QYGDILVRNLRREEEKEEPINMKDIFGAYSMDVI------T 185

  Fly   185 GESLFDCVLGIQARTFTDNPL-PVVRQNHEMSA----ENRGLAIAGAVHGLFPNLP---RWLRPK 241
            |.|   |.:.|.:   .:||. |.|::..::..    :...|::.     |||.|.   ..|...
Mouse   186 GTS---CGVNIDS---LNNPQDPFVQKIKKILKFKFFDPFLLSVV-----LFPFLTPIYEMLNLS 239

  Fly   242 VFPRSHDRFYGQMISEALRLRRSKHQE-RNDFINHLLEMQRELD------LSEEDMASHAMTFMF 299
            :|||....|:.:.:.:..:.|...:|: |.||:..::..|....      ||:.:||:..:.|:|
Mouse   240 IFPRQSMNFFKKFVKKMKKDRLDYNQKNRVDFLQLMMNTQNSKGQESLKALSDLEMAAQTLIFIF 304

  Fly   300 DGLDTTSNSIAHCLLLLGRNPDCQRRLYEELQLVNPGGYLPDLDALIDLPYLSACFNESLRIYPA 364
            .|.|.||.||:..:..|..:||.|::|.:|:....|.......|||:|:.||....|||||:||.
Mouse   305 GGYDGTSTSISFIMYELATHPDVQKKLQDEIDRALPNKAPVTYDALMDMEYLDMVVNESLRLYPV 369

  Fly   365 GGWASKTCTKEYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCK 429
            .....:...|:.|:.|      :.:..|..||:|||.||.||:.:|||:.|.||||......|..
Mouse   370 VSRIDRFSKKDVEIHG------VFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNID 428

  Fly   430 QQGIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEV 467
            .. |::.||||||.|:|||..|...|.|:..::|.|.|
Mouse   429 PY-IYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTV 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	131/467 (28%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	131/469 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820