DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	135/489 - (27%)
Similarity:	240/489 - (49%)	Gaps:	37/489 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLGIATLLGAIYAFLV-SNFGHWRRRGVTEPRALPLFGSFPNMIWP-RQHFTMDMRDIYMHYRN 67
            |||.:..::.::..|.. ...|:|:|||:......||||:..:  || ::|.....||.|..|:|
  Fly     2 LLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKD--WPNKRHIAEIFRDYYFKYKN 64

  Fly    68 T-HSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFEN-----NDASKMVDIAKDRLVALNPFVLE 126
            : :.:.|.:.......:|.:..|:..:.:..|:||||     |:.        |..::...|.:|
  Fly    65 SDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEI--------DDPLSATLFSIE 121

  Fly   127 GEEWRHQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAG--GKDLDCIDLGLRFTGESLF 189
            |::|||.|...:...|:|:::....|:.:|..::.:....|:|.  |:.|:.:||..|:|.:.:.
  Fly   122 GQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQVLEVVDLVARYTADVIG 186

  Fly   190 DCVLGIQARTFTDNPLPVVRQNHEMSAENR-GLAIAGAVHGLFPNLPRWLRPKVFPRSHDRFYGQ 253
            :|..|:...:..|.....|........|:| |..:...:.| ||.|.|.||.|:..:..:.||.:
  Fly   187 NCAFGLNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFLFG-FPKLSRRLRLKLNIQEAEDFYTK 250

  Fly   254 MISEALRLRRSKHQERNDFINHLLEMQR-------ELDLSEEDMASHAMTFMFDGLDTTSNSIAH 311
            ::.|.:..|....::||||::.|:||.:       |..|:..::.:.|..|...|.:|:|.::..
  Fly   251 IVRETIDYRLRTKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMGF 315

  Fly   312 CLLLLGRNPDCQRRLYEELQLVNPGGYLPDL--DALIDLPYLSACFNESLRIYPAGGWASKTCTK 374
            .|..|.||.|.|.:|.||:..|. |.:..:.  :.:.::.||.....|:||.||.....::....
  Fly   316 ALYELARNQDVQDKLREEIGNVF-GKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDT 379

  Fly   375 EYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGN 439
            ::    |.......:..|..|::|...:|.|||:||||::|:||||.|..:. .:....:|.||.
  Fly   380 DF----SPEDPKYFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIA-ARPSCTWLPFGE 439

  Fly   440 GPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRT 473
            |||.|:|:|.|:......||.:::.::..|||.|
  Fly   440 GPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPET 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	126/458 (28%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	126/455 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460925
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900