DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Cyp6a18

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	140/515 - (27%)
Similarity:	249/515 - (48%)	Gaps:	43/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLGIATLLGAIYAFLV-SNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMD--MRDIYMHYRN 67
            |..:|..|.||..::: ....:::|||:...:..||.|   ||...::..|:.  .::.|..|||
  Fly     7 LFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRG---NMEGYKKTRTVHEIHQEYYNKYRN 68

  Fly    68 THS-YVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFEN-----NDASKMVDIAKDRLVALNPFVLE 126
            :.: :||.||.:.|...|::..|..:|.:..||:|.:     |:        ||..::.:.|.|:
  Fly    69 SKAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNE--------KDDPMSAHLFNLD 125

  Fly   127 GEEWRHQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDC 191
            |.:||..|:..|:..|:|:::..:..:..|..:....:..|.:....||..||..|||.:.:..|
  Fly   126 GPQWRLLRSKLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKVSENSILDVRDLVARFTVDVIGTC 190

  Fly   192 VLGIQARTFTDNPLPVVRQNHEMSAENR-GLAIAGAVHGLFPNLPRWLRPKVFPRSHDRFYGQMI 255
            ..||:..:..|.....:........::| |..::|.:.. :|||.|.|...........||.:::
  Fly   191 AFGIKCNSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRS-YPNLARRLGLCRNTAQIQEFYQRIV 254

  Fly   256 SEALRLRRSKHQERNDFINHLLEMQRELD-----------LSEEDMASHAMTFMFDGLDTTSNSI 309
            .|.:.||..::.:||||::.|:.::.:.:           |:.:::.:.|..|...|.||:|:::
  Fly   255 KETVTLREKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTM 319

  Fly   310 AHCLLLLGRNPDCQRRLYEEL-QLVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCT 373
            ...|..|.:||..|.::..|| |::.........:.:.||.||....||:||.|.......:...
  Fly   320 GFALYELAKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAA 384

  Fly   374 KEYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGI-FLGF 437
            |.:.:.|   :....:..|..|::|..|:|:||.:||||:.||||||  ...::.|:..: :|.|
  Fly   385 KRFVVPG---NPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERF--SPEESAKRPSVAWLPF 444

  Fly   438 GNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDP--LIFVGVHKGGIWLQ 495
            |.|||.|:|:|.|...|:..||.:::.|.......|.:....||  .|.:|: ||||.|:
  Fly   445 GEGPRNCIGLRFGQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAILLGI-KGGIQLK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	126/475 (27%)
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	132/484 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460922
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900