DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp28c1 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	135/537 - (25%)
Similarity:	247/537 - (45%)	Gaps:	63/537 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFGSLLLGIATLLGAIYAFLVSNFGHWRRRG--VTEPRALPLFGSFPNMIWPRQHFTMDMR--DI 61
            ||..:||.: |||...:.:|..::.:|.|||  ..:...:| ||.. :.:| ||..:|.:.  |:
  Fly     1 MFSLILLAV-TLLTLAWFYLKRHYEYWERRGFPFEKHSGIP-FGCL-DSVW-RQEKSMGLAIYDV 61

  Fly    62 YMHYRNTHSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVLE 126
            |:  ::....:|.|||..|.:|:.:..|...:....|:.|  :|....||..:|.|.| |.|.|.
  Fly    62 YV--KSKERVLGIYLLFRPAVLIRDADLARRVLAQDFASF--HDRGVYVDEERDPLSA-NIFSLR 121

  Fly   127 GEEWRHQRAVFSTLLTNGRIR----TTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGES 187
            |:.||..|.:.|...|:|:::    |:..|..::...|.:  .:...|.|::|...:...:..:.
  Fly   122 GQSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQK--ELPEEGFKEVDIKKVMQNYAIDI 184

  Fly   188 LFDCVLGIQARTFTDNPLPVVRQNHEMS-AENRGLAIAGAVHGLFPNLPRWLRPKVFPRSHDRFY 251
            :...:.|:...:| :||....|:...:: |.||..|:.|.:..|.|::.::|....|........
  Fly   185 IASTIFGLDVNSF-ENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAM 248

  Fly   252 GQMISEALRLRRSKHQERNDFINHLLEMQRELDLSEED---------------------MASHAM 295
            .|::.|.:..|......|.|.:..|::::....:.|.|                     :.:.|.
  Fly   249 LQIVKETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAF 313

  Fly   296 TFMFDGLDTTSNSIAHCLLLLGRNPDCQRRLYEELQ--LVNPGGYLPDLDALIDLPYLSACFNES 358
            .|...|.:||.::.|..:..|.:.|:..:||.:|:.  |....|.: ..|:|..:.:|..|..|:
  Fly   314 IFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKI-TYDSLNKMEFLDLCVQET 377

  Fly   359 LRIYPAGGWASKTCTKEYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDG 423
            :|.||.....::.||::|.:..::|..|    .|..|::.:|.:|:|.:.:|:|:.:.||||.:.
  Fly   378 IRKYPGLPILNRECTQDYTVPDTNHVIP----KGTPVVISLYGIHHDAEYFPDPETYDPERFSEE 438

  Fly   424 GLKNCKQQGIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDPLIFVGVH 488
            . :|..... |:.||.|||.|:..|:|...:|.|:..|:|.|.|.|..|    :|::      ..
  Fly   439 S-RNYNPTA-FMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSR----SEIE------FE 491

  Fly   489 KGGIWLQFVPRKNVTTK 505
            ..||.|  :|:..|..:
  Fly   492 NSGIAL--IPKHGVRVR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	118/481 (25%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	114/468 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460851
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900