DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Cyp6a20

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_611002.3	Gene:	Cyp6a20 / 36664	FlyBaseID:	FBgn0033980	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	132/512 - (25%)
Similarity:	240/512 - (46%)	Gaps:	42/512 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLGIATLLGAIYAFLVSNFGHWRRRGV--TEPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYRN 67
            ||:|:.|.   :..::..:|.:|:|||:  .||: :| :|:...:: ...||....:..|...||
  Fly     7 LLIGVITF---VAWYVHQHFNYWKRRGIPHDEPK-IP-YGNTSELM-KTVHFADIFKRTYNKLRN 65

  Fly    68 THS--YVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEW 130
            ...  :||.|:.....::|.:......:.:..|..|.:..   :....:|..::.|...::|::|
  Fly    66 KTDGPFVGFYMYFKRMVVVTDIDFAKTVLIREFDKFHDRG---VFHNERDDPLSANLVNIDGQKW 127

  Fly   131 RHQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQ-FIAIKSAGGKDLDCIDLGLRFTGESLFDCVLG 194
            :..|...:...|:|:::|....:..|..:|.: |....||....::..::..|||.:.:..|..|
  Fly   128 KTLRQKLTPTFTSGKMKTMFPTILTVGDELIRVFGETASADSDSMEITNVVARFTADVIGSCAFG 192

  Fly   195 IQARTFTDNPLPVVRQNHEMSAENR-----GLAIAGAVHGLFPNLPRWLRPKVFPRSHDRFYGQM 254
            :...:.:|.....|:.......|.|     .|.:.||     |.|...||.|...:..:.||..:
  Fly   193 LDCHSLSDPKAKFVQMGTTAITERRHGKSMDLLLFGA-----PELAAKLRMKATVQEVEDFYMNI 252

  Fly   255 ISEALRLRRSKHQERNDFINHLLEMQRELD-------LSEEDMASHAMTFMFDGLDTTSNSIAHC 312
            |.:.:..|...:.:|:||::.|:||:.:.|       |:..::|:.|..|...|.:|:|.::...
  Fly   253 IRDTVDYRVKNNVKRHDFVDMLIEMKLKFDNGDKENGLTFNEIAAQAFIFFLAGFETSSTTMGFA 317

  Fly   313 LLLLGRNPDCQRRLYEELQLV--NPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKE 375
            |..|..:.|.|.:|..|:..|  ...|.| |.|::.::.||....:|::|..|..|...:..|:.
  Fly   318 LYELACHQDIQDKLRTEINTVLKQHNGKL-DYDSMREMTYLEKVIDETMRKRPVVGHLIRVATQH 381

  Fly   376 YELRGSHHSEP-LKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGN 439
            |:     |:.| ..:..|..|:||..|:|:||:.||||:.|.||||.:..::. :....||.||:
  Fly   382 YQ-----HTNPKYNIEKGTGVIVPTLAIHHDPEFYPEPEKFIPERFDEDQVQQ-RPACTFLPFGD 440

  Fly   440 GPRQCVGMRLGLAMAKAALAAIVQRFEVVVSP-RTLNGTELDPLIFVGVHKGGIWLQ 495
            |||.|:|:|.|.......:|.::..|:....| :|:...|.....|:...||||.|:
  Fly   441 GPRNCIGLRFGRMQVIVGMALLIHNFKFEFHPTKTVVPLEYRTDDFLLSSKGGIHLK 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	117/470 (25%)
Cyp6a20	NP_611002.3	p450	32..496	CDD:278495	122/481 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.970