DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	133/512 - (25%)
Similarity:	239/512 - (46%)	Gaps:	35/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LGIATLLGAIYAFLVSNFGH----WRR-----RGVTEPRALP--LFGSFPNMIWPRQHFTMDMRD 60
            :|:.::|.||...||   |:    |||     :.:..|...|  |.||...:...|. |:....|
  Fly     1 MGVYSVLLAIVVVLV---GYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRS-FSAIWMD 61

  Fly    61 IYMHYRNTHSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVL 125
            .|..:|.|..:.|.|..:.|.:|||:..|...|.:..|:.|.:..   .....:|..::...|:|
  Fly    62 YYNKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRG---FYHNTEDDPLSGQLFLL 123

  Fly   126 EGEEWRHQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFD 190
            :|::|:..|:..|...|:|:::.....:.:|..:..:...........::..|:..|||.:.:..
  Fly   124 DGQKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGT 188

  Fly   191 CVLGIQARTFTDNPLPVVRQNHEMSAENRGLAIAGAVHGLFPNLPRWLRPKVFPRSHDRFYGQMI 255
            |..||:..:..|..............|.|...|..|....|.||.|.|..|:.....:.|:.:::
  Fly   189 CAFGIECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITLEEAEHFFLRIV 253

  Fly   256 SEALRLRRSKHQERNDFINHLLEMQ----------RELDLSEEDMASHAMTFMFDGLDTTSNSIA 310
            .|.:..|...:..||||::.|::::          ..::|:.|:||:.|..|...|.:|:|.::.
  Fly   254 RETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFETSSTTMG 318

  Fly   311 HCLLLLGRNPDCQRRLYEELQLVNPGGYLPDL--DALIDLPYLSACFNESLRIYPAGGWASKTCT 373
            ..|..|.::.|.|.|:.:|.|.| .|.|..::  :::.|:.||....:|:||:|......::.|.
  Fly   319 FALYELAQHQDIQDRVRKECQEV-IGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVLNRECL 382

  Fly   374 KEYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFG 438
            ::||:.|  |.:.: ::.|..|::|..|:|.|..||..|:.|.|:.|....:|. :....:|.||
  Fly   383 EDYEVPG--HPKYV-IKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKE-RDSVEWLPFG 443

  Fly   439 NGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDPLIFVGVHKGGIWLQ 495
            :|||.|:|||.|...|::.||.::.||:..|..:|..........|:...:.||:|:
  Fly   444 DGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFLK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	120/465 (26%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	122/472 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460920
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900