DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	476	Identity:	139/476 - (29%)
Similarity:	231/476 - (48%)	Gaps:	20/476 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SLLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQ-HFT-MDMRDIYMHYR 66
            :||:.:.|:...:|..|..::.:|.||||...|.:...|:...:  .|. |:| :::| ||..:|
  Fly     3 TLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGL--GRDLHWTDINLR-IYRKFR 64

  Fly    67 NTHSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWR 131
            ....|.|.:......|.:::..|:.:|.:..||.|.  |.....::..|.|.. |...|:|.|||
  Fly    65 GVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFA--DRGLFHNVRDDPLTG-NLLFLDGPEWR 126

  Fly   132 HQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGIQ 196
            ..|...:.:.|:|:::.....|..|...|.|...::..   :::..||..|||.:.:..|..|::
  Fly   127 WLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVG---EIEAKDLCARFTTDVIGSCAFGLE 188

  Fly   197 ARTFTDNPLPVVRQNHEMSAENRGLAIAGAVHGLFPNLPRWLRPKVFPRSHDRFYGQMISEALRL 261
            ..:..|......|....::.|.....:..|.....|.|.|.||.::|......|:...:.:.|..
  Fly   189 CNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQTLDY 253

  Fly   262 RRSKHQERNDFINHLLEMQRE--LD-LSEEDMASHAMTFMFDGLDTTSNSIAHCLLLLGRNPDCQ 323
            ||.::..|||.|..|:|:..|  .| ||.|.:|:.|:.|...|.||:|.:::.||..|..|||.|
  Fly   254 RRRENIHRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYELALNPDVQ 318

  Fly   324 RRL-YEELQLVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKEYELRGSHHSEPL 387
            .|| .|.|.::.........|::.::|||.....|:||.||......:..||||::..|:    |
  Fly   319 ERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQIPNSN----L 379

  Fly   388 KLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNGPRQCVGMRLGLA 452
            .|.||..:::|::::|:||:|||:|:.|.|.||....:| .:....:|.||.|||.|:|.|.|..
  Fly   380 ILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIK-ARHPFAYLPFGEGPRNCIGERFGKL 443

  Fly   453 MAKAALAAIVQRFEVVVSPRT 473
            ..|..|..:::.|:...|.:|
  Fly   444 QVKVGLVYLLRDFKFSRSEKT 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	129/445 (29%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	129/446 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460928
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900