DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp28c1 and Cyp9b1

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	133/516 - (25%)
Similarity:	240/516 - (46%)	Gaps:	30/516 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FGSLLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYR 66
            |..:.|.:||:...::.:....|..:..|.:...:..|..|:.......:..|...:.:.|...|
  Fly     3 FVEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTR 67

  Fly    67 NTHSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLV--ALNPFVLEGEE 129
            : |..||.:.||.|.:.:.:|:|:.:|.|..|.||.|:   :.::|..:|||  .||  |:..:.
  Fly    68 H-HKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNH---QTLNIPNERLVNDMLN--VMRDQH 126

  Fly   130 WRHQRAVFSTLLTNGRIRTTHAIMQR---VCLDLCQFIAIKS----AGGK---DLDCIDLGLRFT 184
            ||:.|:|.:.:.|:.::|....:|..   .||:     .:||    |.|:   :||...|..:.:
  Fly   127 WRNMRSVLTPVFTSAKMRNMFTLMNESFAQCLE-----HLKSSQPIAAGENAFELDMKVLCNKLS 186

  Fly   185 GESLFDCVLGIQARTFTDNPLPVVRQNHEMSAENRGLAIAGAVHGLF-PNLPRWLRPKVFPRSHD 248
            .:.:.....|::..:| |:|........:..|.:|||.....:..|. |.:..:.:..:|..::.
  Fly   187 NDVIATTAFGLKVNSF-DDPENEFHTIGKTLAFSRGLPFLKFMMCLLAPKVFNFFKLTIFDSTNV 250

  Fly   249 RFYGQMISEALRLRRSKHQERNDFINHLLEMQREL--DLSEEDMASHAMTFMFDGLDTTSNSIAH 311
            .::.:::.:|::.|...:..|.|.|..|:|.::|.  :.:::::.:....|.|...:..||.|..
  Fly   251 EYFVRLVVDAMQYREKHNITRPDMIQLLMEAKKESKDNWTDDEIVAQCFIFFFAAFENNSNLICT 315

  Fly   312 CLLLLGRNPDCQRRLYEELQLVNPG--GYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTK 374
            ....|.||.|.|.|||||::.....  |.....||..::.|:....:||||.:.....|.:.|.|
  Fly   316 TAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESLRKWTLSAAADRLCAK 380

  Fly   375 EYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGN 439
            :|.|.....::..:.:.||::.:||..||.|...:|:|..|.||||.:...|:.... .:|.||.
  Fly   381 DYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIPY-TYLPFGV 444

  Fly   440 GPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDPLIFVGVHKGGIWLQFVPRK 500
            |||.|:|.|..:..||..|..::..:::..||||..........|..:...|.|:|.|.||
  Fly   445 GPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRTTRDMWESARGFNIIPTTGFWMQLVSRK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	121/468 (26%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	118/453 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460882
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900