DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Cyp6u1

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	124/494 - (25%)
Similarity:	215/494 - (43%)	Gaps:	57/494 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IATLLGA---IYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYRNTHS 70
            :.|.|||   :||.:..:.|:|:|||:...:...|:|:...::..::|....::|||..|:....
  Fly     8 LLTALGALSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAYKGRAP 72

  Fly    71 YVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWRHQRA 135
            :||.|....|.:|.|:.:||::|..:...||.:..   :........::.|...|:|.:||...|
  Fly    73 FVGFYACLKPFILALDLKLVHQIIFTDAGHFTSRG---LYSNPSGEPLSHNLLQLDGHKWRSLHA 134

  Fly   136 VFSTLLTNGRIRTTHAIMQRVCLDLCQFIA--IKSAGGKDLDCIDLGL---RFTGESLFDCVLGI 195
            ..:.:.       |.|.||::.:.|.|..:  .:..|.|.|..|::..   .:..:.:.....|:
  Fly   135 KSAEVF-------TPANMQKLLVRLSQISSRIQRDLGEKSLQTINISELVGAYNTDVMASMAFGL 192

  Fly   196 QARTFTDNPLPVVRQNHEMSAENRG-----------LAIAGAVHGLFPNLPRWLRPKVFPRSHDR 249
                       |.:.|.|.:...|.           ||:.      ||.:.|.|:.|.:......
  Fly   193 -----------VGQDNVEFAKWTRNYWADFRMWQAYLALE------FPLIARLLQYKSYAEPATA 240

  Fly   250 FYGQMISEALRL-RRSKHQERNDFINHLLEMQRELDLSEEDMASHAMTFMFDGLDTTSNSIAHCL 313
            ::.::....|:| ||...|....|:.  |....|..|::.::|..|..|:..||...:.::|.||
  Fly   241 YFQKVALSQLQLHRRRDRQPLQTFLQ--LYSNAEKPLTDIEIAGQAFGFVLAGLGPLNATLAFCL 303

  Fly   314 LLLGRNPDCQRRLYEELQ--LVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKEY 376
            ..|.|.|:.|.|...|:.  |...||.:.. :.|.:|.|.....||:||::....:..:..|||:
  Fly   304 YELARQPEVQDRTRLEINKALEEHGGQVTP-ECLRELRYTKQVLNETLRLHTPHPFLLRRATKEF 367

  Fly   377 ELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNGP 441
            |:.||    ...:..|::|::|..|:|.||.:|..|..|.|||| :...:..:....||.||:|.
  Fly   368 EVPGS----VFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERF-EEQARRSRPAAAFLPFGDGL 427

  Fly   442 RQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELD 480
            |.|:..|.........|.|::::.....|..|....|.|
  Fly   428 RGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYD 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	113/465 (24%)
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	113/464 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460930
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900