DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Cyp6w1

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	136/517 - (26%)
Similarity:	225/517 - (43%)	Gaps:	46/517 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIY--MHYRN 67
            ||||..|::  .|.:.......|.|.||...|..|:.|.....:..:..|...::..:  ..:.|
  Fly     5 LLLGSLTIV--FYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHEAPGFEN 67

  Fly    68 THSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWRH 132
             ..:||.|:...|.|::.:..|:..:.:..|.:|  |:.....|...|.|...|.|......||.
  Fly    68 -EPFVGVYMTHRPALVIRDLELIKTVMIKKFQYF--NNRVLQTDPHNDALGYKNLFFARSPGWRE 129

  Fly   133 QRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGIQA 197
            .|...|.:.|:|:|:..:.:|.::..:| |..|.:...|.::...||..|||.:.:.....|::|
  Fly   130 LRTKISPVFTSGKIKQMYPLMVKIGKNL-QDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGVEA 193

  Fly   198 RTFTDNPLPVVRQNHEMSAENRGLAIAGAVHGLFPNLPRWLRPKVFPRSHDRFYGQMISEALRLR 262
            ....|........|..:.:......|..|:..:.|.|....|.|:|.|...:|....::..|:.|
  Fly   194 NALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIRSSVNYVLKER 258

  Fly   263 RSKHQERNDFINHLL-----------EMQRELDLSEEDMASHAMTFMFDGLDTTSNSIAHCLLLL 316
            ....::|||.|:.||           :|.:|:||  :.:.:.|..|...|.:|:::::...|..|
  Fly   259 ERTGEKRNDLIDILLALKREAAANPGKMSKEVDL--DYLVAQAAVFQTAGFETSASTMTMTLYEL 321

  Fly   317 GRNPDCQRRLYEELQLVNPGGYLPDLD-----ALIDLPYLSACFNESLRIYPAGGWASKTCTKEY 376
            .:|...|.||.:|:.     .:..|.|     .:.::||||...||:||.||..|:..:.|::..
  Fly   322 AKNEALQDRLRQEIV-----DFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQPA 381

  Fly   377 ELRGSHHSEPLKLRPGDHVMVP----IY----ALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGI 433
            |      .|...|.|..::.:|    ||    |:|.||..:|:|:.:.||||......|.....
  Fly   382 E------GERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDA- 439

  Fly   434 FLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDPLIFVGVHKGGIWLQ 495
            ::.||.|||.|:||||||..:|..|..|::........:|:...|..|...|...|..|.|:
  Fly   440 YMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIILR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	123/477 (26%)
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	125/484 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460812
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900