DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Cyp308a1

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	168/512 - (32%)
Similarity:	244/512 - (47%)	Gaps:	44/512 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYRNTH 69
            |.|.:..||.|...|......||||.|:..|...||.|:..:....|:.:....::||.  ||..
  Fly     2 LPLVLFILLAATLLFWKWQGNHWRRLGLEAPFGWPLVGNMLDFALGRRSYGEIYQEIYT--RNPG 64

  Fly    70 -SYVGCY-LLRAPKLLVLEPRLVYEIYVSA-FSHFENNDASKMVDIAKDRLVALNPFVLEGEEWR 131
             .|||.| |...|.:||.:..|:.:|.|.. |:...:|  :..||..:|.|.:.|||:..|:.||
  Fly    65 LKYVGFYRLFNEPAILVRDQELLRQILVGRNFADCADN--AVYVDHQRDVLASHNPFIANGDRWR 127

  Fly   132 HQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGIQ 196
            ..||....|.|..|:|.|...:.|.    ||.:..:...|: .:..||..|:|.:.:...:.|:.
  Fly   128 VLRADLVPLFTPSRVRQTLPHVARA----CQLLRDQVPLGR-FEAKDLATRYTLQVVASAIFGLD 187

  Fly   197 ARTFTDNPLPVVRQNHEMSAENRGLA--IAGAVHGLF--------PNLPRWLRPKVFPRSHDRFY 251
            |.....:    :|..||.|.....||  ...:|..|.        |.|.|.:..:..|.....::
  Fly   188 AHCLGIH----MRVAHEPSRWLEWLAPLFQPSVWSLLETMSLLHTPRLGRLIGHRYVPLPLQHWF 248

  Fly   252 GQMISEALRLRRSKHQERNDFINHLLEMQRELDLSEEDMASHAMTFMFDGLDTTSNSIAHCLLLL 316
            .::: ||       ....::.:..|.|.:|  .|.:|::|.||.|.:.:|.:|::..:|..|..|
  Fly   249 RELV-EA-------RSGGDNLLQWLAESKR--GLGKEELAGHATTLLLEGYETSAMLLAFALYEL 303

  Fly   317 GRNPDCQRRLYEELQLV--NPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKEYEL- 378
            ..|.|.||||:.||..|  ...|.|.|..||.:|.|..|...|:||::||.....|.|||.:.|
  Fly   304 ALNEDAQRRLHIELDEVAQRHAGNLIDPVALGELRYSEAALLEALRLHPAMQALQKRCTKTFTLP 368

  Fly   379 -RGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNGPR 442
             :.|..|..||:..|..:::|:.|:|.||.|||.|:.|||||||:.....|:    |||||.|||
  Fly   369 DQKSGASSELKVHLGTVLVLPVQAIHLDPALYPAPNQFRPERFLNQPPMGCR----FLGFGAGPR 429

  Fly   443 QCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDPLIFVGVHKGGIWLQFVPR 499
            .|.||||||...||||..::|...|.::.......|:.||.|:...:.||||.|..|
  Fly   430 MCPGMRLGLLQTKAALTTLLQDHCVQLADEDQCRVEVSPLTFLTASRNGIWLSFKRR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	151/468 (32%)
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	153/475 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472966
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900