DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	554	Identity:	145/554 - (26%)
Similarity:	228/554 - (41%)	Gaps:	106/554 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFGSLLLGIATLLGAIYAFLVSNFGHW-----RRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRD 60
            ||....|.:...|..:...|:..:|.|     ::.|:..||.||..|:..:......:|.::...
Zfish     1 MFDLSSLSVTWTLVVLVITLLLIYGVWPHGFFKKLGIPGPRPLPFVGTALSYSKGICNFDIECSK 65

  Fly    61 IYMHYRNTHSYVGCYLLRAPKLLVLEPRLVYEIYV-SAFSHFENNDASKMVDIAKDRLVALNPF- 123
            .|      ....|.|..|.|.|||.:..::..|.| ..:|.|.|. .:...|:       :.||
Zfish    66 KY------GKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNR-RNMNPDL-------VGPFA 116

  Fly   124 ----VLEGEEWRHQRAVFSTLLTNGRIR------TTHA--------------------IMQRVCL 158
                :::.|.||..|:..|...|:||::      .|||                    ::....|
Zfish   117 DGITLVKDERWRRIRSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKKDPNLPLKIKDVVAPYSL 181

  Fly   159 DLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGIQARTFTDNPLPVVRQNHEMSAENRGLAI 223
            |    :...|:...|.|.|:     ..:..|  |..|:: .|..|||             ..|.:
Zfish   182 D----VVASSSFSVDFDSIN-----NPDDPF--VTSIKS-FFNINPL-------------SPLFL 221

  Fly   224 AGAVHGLFPNLPRWLRPKVFPRSHDRFYGQMISEALRLRRSKHQERN---DFINHLLEMQRELD- 284
            ..|......||...:...||.||...||    .:|||..:.:|.|.|   ||:..:::.|...|
Zfish   222 LLAFCPSAANLLAKMGISVFSRSTTDFY----YKALRKIKDEHNESNGRVDFLKLMIQNQIPDDQ 282

  Fly   285 ------------LSEEDMASHAMTFMFDGLDTTSNSIAHCLLLLGRNPDCQRRLYEELQLVNPGG 337
                        |::.::.|.:..|:..|.:|||.::::.|..|..||||..:|.||:....|..
Zfish   283 VKDTASEQPVKGLTDHEILSQSFIFILGGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKNFPLD 347

  Fly   338 YLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKEYELRGSHHSEPLKLRPGDHVMVPIYAL 402
            .....|||:.:.||....:||:|::|||....:.|.|..|:.|      :.:.....|.:|:|.|
Zfish   348 IPITYDALMRMDYLEMAIHESMRVFPAGPRLERVCKKTVEING------ITIPKNTLVGIPLYVL 406

  Fly   403 HNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEV 467
            ..||||:..|:.|:||||.... |....|..|:.||.|||.|:|||..|.|.|..:..::|::.|
Zfish   407 SRDPDLWESPNEFKPERFSPES-KTEINQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTV 470

  Fly   468 VVSPRTLNGTELDPLIFVGVHKGGIWLQFVPRKN 501
            .....|....:|:   |....|..|.|:.:||.:
Zfish   471 ETCKETQIPVQLN---FFFQPKVPITLKLIPRSH 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	132/499 (26%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	135/510 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910