DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	127/542 - (23%)
Similarity:	232/542 - (42%)	Gaps:	86/542 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHF---TMDMRDIYMHYRNTHSYVG 73
            ||..:..:..|.|...|:.|:..|...|..|   |:::.||.|   .:::|:.|      ....|
  Rat    24 LLALLKWYSTSAFSRLRKLGIRHPEPSPFVG---NLMFFRQGFWESHLELRERY------GPLCG 79

  Fly    74 CYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWRHQRAVFS 138
            .||.|...:::.:|.::.|:.|..||:|.|..||.:    :.:|:|.:..:|....|...|....
  Rat    80 YYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGL----EPKLIADSVLMLRDRRWEEVRGALM 140

  Fly   139 TLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGIQARTFTDN 203
            :..:..::.....::.:.|..|...:...:|.|...|.......||...:.....||:..:....
  Rat   141 SAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAP 205

  Fly   204 PLPVVRQNHEMSAENRGLAIAGAVHGLFPNLPRWLRP--KVFPRSH----DRFYGQMISE--ALR 260
            ..|.|:....:.|    .:....:..|..:.|..:.|  ::.|..:    :.|:..:|..  |||
  Rat   206 EDPFVQHCQRVFA----FSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALR 266

  Fly   261 LRRSKHQERNDFINHLLEMQRELD-----------------------------------LSEEDM 290
            .:::..:.|.||:..:|:.||.:.                                   |:.:::
  Rat   267 DKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEI 331

  Fly   291 ASHAMTFMFDGLDTTSNSIAHCLLLLGRNPDCQRRLYEELQLVNPGGYLPDLDALID-LPYLSAC 354
            |..|..|:..|.:.|:|:::....||..:|:||.||.:|:.|.......|:...|.: ||||...
  Rat   332 AGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMV 396

  Fly   355 FNESLRIYPAGGWASKTCTKEYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPER 419
            ..|:||:||.....::...::.|:.|.|      :..|..:.:.:.|||:||:.:|.|:.|.|||
  Rat   397 VAETLRMYPPAFRFTREAAQDCEVLGQH------IPAGSVLEIAVGALHHDPEHWPNPETFDPER 455

  Fly   420 F-LDGGLKNCKQQGIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELD--- 480
            | .:..|:  ::...:|.||.|||.|:|:||||.:.|..|..::.:|.....|.|....:|:
  Rat   456 FTAEARLQ--QKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKS 518

  Fly   481 ---PLIFVGVHKGGIWLQFVPR 499
               |       |.|::::.|.|
  Rat   519 ALCP-------KNGVYVKIVSR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	117/505 (23%)
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	119/514 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780