DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28c1 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	132/484 - (27%)
Similarity:	232/484 - (47%)	Gaps:	62/484 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYRNTHSYVG 73
            :||:|..:|.:..|..|::::.|::.|:.||..|   |::..|..|....|..:..|.:..   |
  Rat    15 LATILVLLYLYGTSTHGNFKKLGISGPKPLPFVG---NILAYRHGFWEFDRHCHKKYGDIW---G 73

  Fly    74 CYLLRAPKLLVLEPRLVYEIYV-SAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWRHQRAVF 137
            .|..|.|.|.:.:|.::..:.| ..:|.|.|..:.....|.| :.:.|:    |.|||:..|.:.
  Rat    74 FYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSFGPAGILK-KAITLS----EDEEWKRLRTLL 133

  Fly   138 STLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGIQARTFTD 202
            |...|:|:::....|:.:....|.:.:..::..|..:...|:...::.:.:.....|:...:..:
  Rat   134 SPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLNN 198

  Fly   203 NPLPVVRQNHEMSAEN----RGLAIAGAVHGLFPNLPRWLRP-------KVFPRSHDRFYGQMIS 256
            ...|.|::..::...|    ..|::.     |||    :|.|       .|||:...:|:...:.
  Rat   199 PQNPFVQKVKKLLKFNFLDPFFLSVI-----LFP----FLTPVFEAFDITVFPKDVMKFFRTSVE 254

  Fly   257 EALRLRRSKHQE----RNDFINHLLEMQRELD------LSEEDMASHAMTFMFDGLDTTSNSIAH 311
               |::.::.||    |.||:..::..|...|      |::.::.:.::.|:|.|.:|||::::.
  Rat   255 ---RMKENRMQEKVKQRLDFLQLMINSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSALSF 316

  Fly   312 CLLLLGRNPDCQRRLYEELQLVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKEY 376
            .|.||..:||.|::|.:|:....|.......|.|:::.||....||:||::|.||...:.|.|:.
  Rat   317 ALYLLATHPDLQKKLQDEIDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDV 381

  Fly   377 ELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQG-----IFLG 436
            |:.|      :.:..|..||||.:|||.||..:|||:.|.||||      ..|.|.     |:|.
  Rat   382 EING------VFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERF------RKKNQDSINPYIYLP 434

  Fly   437 FGNGPRQCVGMRLGLAMAKAALAAIVQRF 465
            ||||||.|:|||..|...|.||..::|.|
  Rat   435 FGNGPRNCIGMRFALMNMKIALVRVLQNF 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	125/458 (27%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	125/460 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820