Protein Alignment Cyp28c1 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_001259464.1
• Gene: Cyp28c1 / 32138
• FlyBaseID: FBgn0030339
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 136/519 - (26%)
• Similarity: 238/519 - (45%)
• Gaps: 57/519 - (10%)

  Fly     5 LLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIYMHYRNTH 69
            |||.::.:|  :|.:...:.|.:::.|:..|..||..|   |::...:.|.|...:.:..|....
Human    13 LLLAVSLVL--LYLYGTHSHGLFKKLGIPGPTPLPFLG---NILSYHKGFCMFDMECHKKYGKVW 72

  Fly    70 SYVGCYLLRAPKLLVLEPRLVYEIYV-SAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWRHQ 133
               |.|..:.|.|.:.:|.::..:.| ..:|.|.|......|...|..:     .:.|.|||:..
Human    73 ---GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAI-----SIAEDEEWKRL 129

  Fly   134 RAVFSTLLTNGRIRTTHAIMQRVCLDLCQFIAIKSAGGKDLDCIDLGLRFTGESLFDCVLGIQAR 198
            |::.|...|:|:::....|:.:....|.:.:..::..||.:...|:...::.:.:.....|:...
Human   130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194

  Fly   199 TFTDNPLPVVRQNHEM----SAENRGLAIAGAVHGLFPNL-P--RWLRPKVFPRSHDRFYGQMIS 256
            :..:...|.|....::    ..:...|:|.     :||.| |  ..|...||||....|..:.:.
Human   195 SLNNPQDPFVENTKKLLRFDFLDPFFLSIT-----VFPFLIPILEVLNICVFPREVTNFLRKSVK 254

  Fly   257 EALRLRRSK----HQERNDFINHLLEMQRELD------LSEEDMASHAMTFMFDGLDTTSNSIAH 311
               |::.|:    .:.|.||:..:::.|...:      ||:.::.:.::.|:|.|.:|||:.::.
Human   255 ---RMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSF 316

  Fly   312 CLLLLGRNPDCQRRLYEELQLVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWASKTCTKEY 376
            .:..|..:||.|::|.||:..|.|....|..|.::.:.||....||:||::|......:.|.|:.
Human   317 IMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDV 381

  Fly   377 ELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQGIFLGFGNGP 441
            |:.|      :.:..|..||:|.||||.||..:.||:.|.||||......|.... |:..||:||
Human   382 EING------MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY-IYTPFGSGP 439

  Fly   442 RQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELDPLIFVGVHKGGIWLQFVPRKNVTTK 505
            |.|:|||..|...|.||..::|.|    |.:....|:: ||   .:..||: ||  |.|.|..|
Human   440 RNCIGMRFALMNMKLALIRVLQNF----SFKPCKETQI-PL---KLSLGGL-LQ--PEKPVVLK 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	121/469 (26%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	129/491 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920