Protein Alignment Cyp28c1 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_572752.1
• Gene: Cyp28c1 / 32138
• FlyBaseID: FBgn0030339
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 148/573 - (25%)
• Similarity: 229/573 - (39%)
• Gaps: 147/573 - (25%)

  Fly     6 LLGIATLLGAIYAF---LVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTM------DMRDI 61
            :..::|||..:..|   |:..|....|......|.|..|...|...|...|..|      .::|.
Human    21 IYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDE 85

  Fly    62 YMHYRNTHSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLV--ALNPF- 123
            .....|.|..:..::.....|||    ||:..|:....     .||..: ..||.|.  .|.|:
Human    86 KKVLDNMHHVLLVWMGPVLPLLV----LVHPDYIKPLL-----GASAAI-APKDDLFYGFLKPWL 140

  Fly   124 -----VLEGEEW-RHQRAV-----FSTL-----LTNGRIRTTHAIMQR------VCLDLCQFIAI 166
                 :.:|::| ||:|.:     |..|     :.|......||..:.      |.||:.:.|::
Human   141 GDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISL 205

  Fly   167 KSAGGKDLDCIDLGLRFTGESLFDCVLGIQA---RTFTD--------NPLPVVRQ---NHEM--- 214
                            .|.:||..||....:   ...:|        :.|.|.||   :|.:
Human   206 ----------------MTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFI 254

  Fly   215 ---SAENRGLAIA-GAVHGLFPNLPRWLRPKVFPRSHDRFYGQMISE---ALRLR------RSKH 266
               ||:.|....| ..||                    .|..::|.|   |||.:      ::|.
Human   255 YYRSADGRRFRQACDMVH--------------------HFTTEVIQERRRALRQQGAEAWLKAKQ 299

  Fly   267 QERNDFINHLLEMQRELD---LSEEDMASHAMTFMFDGLDTTSNSIAHCLLLLGRNPDCQRRLYE 328
            .:..|||:.|| :.|:.|   ||:||:.:.|.||||:|.||||:.|:..|..|.:.|:.|.:..|
Human   300 GKTLDFIDVLL-LARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCRE 363

  Fly   329 ELQLVNPGGYLPDL--DALIDLPYLSACFNESLRIYPAGGWASKTCTKEYELRGSHHSEPLKLRP 391
            |:|.|..|..|.:|  |.|..||:.:.|..||||.||.....|:.||::.:|...      ::.|
Human   364 EIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDG------RIIP 422

  Fly   392 -GDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNCKQQG--IFLGFGNGPRQCVGMRLGLAM 453
             |...:|.||..|::|.::|:..|:.|.||   ...|.:|:.  .::.|..|||.|:|....:|.
Human   423 KGIICLVSIYGTHHNPTVWPDSKVYNPYRF---DPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAE 484

  Fly   454 AKAALAAIVQRFEVVV--------SPRTLNGTELDPLIFVGVHKGGIWLQFVP 498
            .:..:|..:.||.:.|        .|..:..||           .|:||:..|
Human   485 LRVVVALTLLRFRLSVDRTRKVRRKPELILRTE-----------NGLWLKVEP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28c1	NP_572752.1	CYP6-like	67..493	CDD:410679	130/496 (26%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	132/507 (26%)