DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rudhira and ATG18G

DIOPT Version :9

Sequence 1:	NP_001368979.1	Gene:	rudhira / 32136	FlyBaseID:	FBgn0266019	Length:	2162	Species:	Drosophila melanogaster
Sequence 2:	NP_171837.7	Gene:	ATG18G / 838702	AraportID:	AT1G03380	Length:	959	Species:	Arabidopsis thaliana

Alignment Length:	1149	Identity:	270/1149 - (23%)
Similarity:	410/1149 - (35%)	Gaps:	355/1149 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VVGSGIGLGSGSGTGLGSGSTGGSKSGAAVPAIVPPQTVSDRSILDSAIGFINDVTLANQPVQDP 77
            ::.|.:...|.:.|.:.|..   ..:||:|.|.:                         ...:|.
plant    19 IISSCLKTVSANATNVASSV---RSAGASVAASI-------------------------SAAEDD 55

  Fly    78 KDTITWARFETCADVSDPRFGDDWELE-GNAAPPLLLILGYGLGVQVWAIPANGEAVEVLSWRHG 141
            ||.:|||.|..              || |......:|:|||..|.||:.:.......|::|.|.|
plant    56 KDQVTWAGFGI--------------LELGQHVTRHVLLLGYQNGFQVFDVEDASNFNELVSKRGG 106

  Fly   142 VVTALRVLPTPATAAALDENGRADEPVDSFAEKRPLVAFVDGGSAAASGLLAGSSGLGLGGGGGG 206
            .|:.|::.|.||.:.  |..|        |....||:..|.|..       ...:|||......|
plant   107 PVSFLQMQPLPARSG--DHEG--------FWNSHPLLLVVAGDE-------TNGTGLGHSFSQNG 154

  Fly   207 VTTVGGSVGGVSGIGVSASAQFSAVNFMSLKTGVQVKTIKFKNAVLDIQANRSAVVITFHERIAV 271
            .....||....:|..::..   :.|.|.||::...|..::|:::|..|:.:...|.:....:|..
plant   155 SLARDGSSDSKAGDAINYP---TTVRFYSLRSHSYVYVLRFRSSVCMIRCSSRVVAVGLANQIYC 216

  Fly   272 FDARTLEDRLTITTCYPSP----------GINPNPIALGPRWLAYAEH----------------- 309
            .||.|||::.::.| ||.|          .:...|:|:||||||||..
plant   217 VDALTLENKFSVLT-YPVPQPVRQGTTRVNVGYGPMAVGPRWLAYASKSSMTMKTGRLSPQTFTS 280

  Fly   310 --KLLHSKRSGGGCDGEGVPSYTAT-VLNAAKSLSKGLREFGEQVAAGLT---------GTTAGS 362
              .|..|..|||.       |:.|. .:.::|.|:.||...|:.....|:         |:|  |
plant   281 SPSLSPSSSSGGS-------SFMARYAMESSKQLANGLINLGDMGYKTLSKYCQDMLPDGST--S 336

  Fly   363 GASSKSSSFDSASGGPDAKQSGVVTIIDVKHPVKDYSPTSGTPLSSTAGSQGGGDPIVAHFVAHS 427
            .||..:........|.||:.:|:|.:.|:         .||.              :|:.|.||:
plant   337 PASPNAIWKVGGVSGSDAENAGMVAVKDL---------VSGA--------------LVSQFKAHT 378

  Fly   428 EALVAMEFDSSGMLLLTADRRGHDFHVFRVQP---HPVGPSLA----AVH-HLYVLHRGDTSAKV 484
            ..:.|:.||.||.||:||...|::.:||::.|   |.....|:    :.| ||:.||||.|||.|
plant   379 SPISALCFDPSGTLLVTASVCGNNINVFQIMPSRSHNAPGDLSYEWESSHVHLFKLHRGITSAIV 443

  Fly   485 QHIAFSLDSRWAAVSTLRGTTHVFPITPYGGAMGVRTHTSLHVVNKLSRFHRSAGLGADGRSSSP 549
            |.|.||..|:|.|:.:.:||.|:|                  |:|       |:|..|   :..|
plant   444 QDICFSQQSQWVAIISSKGTCHIF------------------VLN-------SSGSDA---AFQP 480

  Fly   550 ISHSESTTFVQSLQPYHNPTLPPYPRPSVVQPLAQLRQPFTLGSPPGSAGLG-------GGVGGG 607
            ....|.|....|..|:.           ..|.|:..:|..   |||.:..|.       ...|..
plant   481 CEGEEPTRLPASSLPWW-----------FTQSLSSNQQSL---SPPTAVALSVVSRIKYSSFGWL 531

  Fly   608 GVMGSGVSAGGHGVGVGVGSNSQRQRQRLSSLSDDSGKPLSVCSIFAKSRSWLLEPPMATREQPH 672
            ..:.:..:|....|.|..|                     :|.::|.||         .|.:...
plant   532 NTVSNATTAATGKVFVPSG---------------------AVAAVFHKS---------VTHDLQL 566

  Fly   673 RVQRKAVDSLFVMAGHGALIQYD-------------LDTKLASHVAKEKICDDTPIELEVEARAQ 724
            ..:..|::.:.|....|.::|::             |..:..|||..::  ||  :.::||....
plant   567 NSRTNALEHILVYTPSGHVVQHELLPSVCTESPENGLRVQKTSHVQVQE--DD--LRVKVEPIQW 627

  Fly   725 WNLGRRKD--GSQEIAPPL---------GLDNWLIKDRHASLLLDSANQFDD----------PDE 768
            |::.||.|  .::|..|..         .:.|.|.....|.|.||..:.|.:          |.|
plant   628 WDVCRRSDWLETEERLPKSITEKQYDLETVSNHLTSHEDACLSLDMNSHFSEDKYLKSCSEKPPE 692

  Fly   769 RTESWLAQVEIITHAG--PHRRLWMGPQFVFKNYNTPSGSN-------LNHVDAEAVEIGVSKTT 824
            |:..:|:..|:...:|  |   :|...:..|...::|..|:       :..|.|..:||...|
plant   693 RSHCYLSNFEVKVTSGMLP---VWQNSKISFHVMDSPRDSSSTGGEFEIEKVPAHELEIKQKK-- 752

  Fly   825 TTTLP------STAASSALGLGTIIGKDRSSPLNMPLSAATSVGGAGIGSSAVTGRSGAGV---- 879
              .||      ||.|:.         :||.|......||.        ||..|.|:....:
plant   753 --LLPVFDHFHSTKATL---------EDRFSMKCYHTSAT--------GSHQVNGKICQDIINCH 798

  Fly   880 --PVLIESGSYSSIEQSPKLMDRFRHGHLDSDYGHGDTRLKEDL-----------------ADAM 925
              |..|||.. ||.|.|.|.|:...    |||  |....:|..|                 |:..
plant   799 SKPGSIESAE-SSEEGSTKQMENLH----DSD--HMSNSIKSSLPLYPTVNGIYKEIEKNNANGW 856

  Fly   926 RESPSTA--AARRETTAASVDQAAPPCGDH-----LATGASPASADLLAAGAGGSA-SSNCDNVC 982
            .|.|.||  :..:||...:.....|...|.     |:||..|       .|.|.:. ..:|..|.
plant   857 MEKPVTAKLSTLKETRITNGFTTPPILTDSVNEQMLSTGKPP-------MGFGFALHEEHCKAVA 914

  Fly   983 YYDALAEHESLNDLDEVVEDQH--------QHTDAETHLHSMDS 1018
              |...||.. ..||||....|        :....:..:|.|.|
plant   915 --DPKEEHLK-KKLDEVTNVHHLNVNNNNTEKLQGDKMVHGMVS 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rudhira	NP_001368979.1	BCAS3	648..818	CDD:403626	43/212 (20%)
ATG18G	NP_171837.7	WD40	367..>397	CDD:197651	14/43 (33%)
		WD40 repeat	381..417	CDD:293791	14/35 (40%)
		BCAS3	512..748	CDD:372146	50/272 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	133	1.000	Domainoid score	I1643
eggNOG	1	0.900	-	-		E1_KOG2109
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005577
OrthoInspector	1	1.000	-	-		otm3307
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13268
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3991
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.870