DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and LHS1

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_012850.1	Gene:	LHS1 / 853789	SGDID:	S000001556	Length:	881	Species:	Saccharomyces cerevisiae

Alignment Length:	723	Identity:	166/723 - (22%)
Similarity:	307/723 - (42%)	Gaps:	130/723 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLAVVAFVGLSLGEEKKEKDKELGTVIGIDLG-TTYSCVGVYKNGRVEIIANDQGNR-------- 61
            ||.:.|||.:.          .|..|:|:|.| .....:.|.....:|::...:..|
Yeast     7 LLFLTAFVAIG----------SLAAVLGVDYGQQNIKAIVVSPQAPLELVLTPEAKRKEISGLSI 61

  Fly    62 -ITPSYVAFTADG-ERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVEKN 124
             ..|.|.....:| ||:.|.|..:..|..|:||:...|.|:|:...|..           .|...
Yeast    62 KRLPGYGKDDPNGIERIYGSAVGSLATRFPQNTLLHLKPLLGKSLEDET-----------TVTLY 115

  Fly   125 SKPHIS---VDTSQGAKVFAP-------EEISAMVLGKMKETAEAYLGKK-------VTHAVVTV 172
            ||.|..   |.|::....|..       ||:.||.:.::...|.:.|..:       |.....|:
Yeast   116 SKQHPGLEMVSTNRSTIAFLVDNVEYPLEELVAMNVQEIANRANSLLKDRDARTEDFVNKMSFTI 180

  Fly   173 PAYFNDAQRQATKDA-GVIAGLQVMRIINEPTAAAIAYGLDKKE---GE-KNVLVFDLGGGTFDV 232
            |.:|:..||:|..|| .:..|::...:::|..:.|:.:.|.:::   || ::.:|:|:|.|:...
Yeast   181 PDFFDQHQRKALLDASSITTGIEETYLVSEGMSVAVNFVLKQRQFPPGEQQHYIVYDMGSGSIKA 245

  Fly   233 SL------------LTIDNGVFEVVATNGDTHLGGE----DFDQRVMDHFIKLYKKKKGKDIRKD 281
            |:            :||:   ||....|  .||||.    |....:.:.|::.:...:..::..:
Yeast   246 SMFSILQPEDTTQPVTIE---FEGYGYN--PHLGGAKFTMDIGSLIENKFLETHPAIRTDELHAN 305

  Fly   282 NRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKP----V 342
            .:|:.|:.:..||||..||.:.:..|.|||.....||..::||.:|||...|.....:||    |
Yeast   306 PKALAKINQAAEKAKLILSANSEASINIESLINDIDFRTSITRQEFEEFIADSLLDIVKPINDAV 370

  Fly   343 QKVLEDADMNKKDVHEIVLVGGSTRIPKVQ-QLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLS 406
            .|.......|..:::.::|.|||:|||.|| ||:| ....::..|.:|.||:...|..::...||
Yeast   371 TKQFGGYGTNLPEINGVILAGGSSRIPIVQDQLIK-LVSEEKVLRNVNADESAVNGVVMRGIKLS 434

  Fly   407 GEQDTDAIVLLD--VNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGE 469
            ....|..:.::|  ||..:..:.. ...:..:..|.:..|.|.|.:.:|.....:..||.::|..
Yeast   435 NSFKTKPLNVVDRSVNTYSFKLSN-ESELYDVFTRGSAYPNKTSILTNTTDSIPNNFTIDLFENG 498

  Fly   470 R---------PMTKDNHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQV--------SAEDKG 517
            :         ...|:::...|.. :|:        ...::|::.::.:..:        |..|.|
Yeast   499 KLFETITVNSGAIKNSYSSDKCS-SGV--------AYNITFDLSSDRLFSIQEVNCICQSENDIG 554

  Fly   518 TG----NK-EKIVITNDQ---NRLTPEDIDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKN 574
            ..    || .::..|::.   .||:|.:..|:....:....:||:..:..|:.|.|||..|..:|
Yeast   555 NSKQIKNKGSRLAFTSEDVEIKRLSPSERSRLHEHIKLLDKQDKERFQFQENLNVLESNLYDARN 619

  Fly   575 QIGDKDKLGAKLSDDEKNKLESAIDESIK----WLEQ-NPDADPEEYKKQKKDLEAIVQPVIAKL 634
            .:.|.:    .:.:..|:::|. :.|.:|    |||. :.|.|||:...:.:::..:.:.:  :|
Yeast   620 LLMDDE----VMQNGPKSQVEE-LSEMVKVYLDWLEDASFDTDPEDIVSRIREIGILKKKI--EL 677

  Fly   635 YQGAGGAP 642
            |..:...|
Yeast   678 YMDSAKEP 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	108/427 (25%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	159/697 (23%)
LHS1	NP_012850.1	HYOU1-like_NBD	23..430	CDD:212672	107/423 (25%)
LHS1	NP_012850.1	Smc	<581..737	CDD:224117	25/112 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770