DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and KAR2

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_012500.3	Gene:	KAR2 / 853418	SGDID:	S000003571	Length:	682	Species:	Saccharomyces cerevisiae

Alignment Length:	629	Identity:	421/629 - (66%)
Similarity:	506/629 - (80%)	Gaps:	10/629 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93
            |||||||||||||||.|.|||:.||:||:||||||||||||| |.|||||||||||:..||:||:
Yeast    50 GTVIGIDLGTTYSCVAVMKNGKTEILANEQGNRITPSYVAFT-DDERLIGDAAKNQVAANPQNTI 113

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            ||.|||||.:::|.:||.|||..||.||.|:.||.:.|......|||.|||||.|:|||||:.||
Yeast   114 FDIKRLIGLKYNDRSVQKDIKHLPFNVVNKDGKPAVEVSVKGEKKVFTPEEISGMILGKMKQIAE 178

  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEGEKNVLVF 223
            .|||.|||||||||||||||||||||||||.||||.|:||:||||||||||||||.:.|..::|:
Yeast   179 DYLGTKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKSDKEHQIIVY 243

  Fly   224 DLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKL 288
            ||||||||||||:|:||||||.||:|||||||||||.:::...||.:|||.|.|:..:|:|:.||
Yeast   244 DLGGGTFDVSLLSIENGVFEVQATSGDTHLGGEDFDYKIVRQLIKAFKKKHGIDVSDNNKALAKL 308

  Fly   289 RREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNK 353
            :||.||||||||.....||||:||.:|.|.|||||||||||||||||:.|||||:|||:|:.:.|
Yeast   309 KREAEKAKRALSSQMSTRIEIDSFVDGIDLSETLTRAKFEELNLDLFKKTLKPVEKVLQDSGLEK 373

  Fly   354 KDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLD 418
            |||.:||||||||||||||||::.:|.||:.|:||||||||||||||||||||||:..:.|||||
Yeast   374 KDVDDIVLVGGSTRIPKVQQLLESYFDGKKASKGINPDEAVAYGAAVQAGVLSGEEGVEDIVLLD 438

  Fly   419 VNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFD 483
            ||.||:||||.|||||.||.|||.|||||||:||||.|||.||.|:||||||.|:|||:|||||:
Yeast   439 VNALTLGIETTGGVMTPLIKRNTAIPTKKSQIFSTAVDNQPTVMIKVYEGERAMSKDNNLLGKFE 503

  Fly   484 LTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDAEKF 548
            ||||||||||:|||||:|.:||||||:|||.|||||..|.|.||||:.|||.|:||||:.:||||
Yeast   504 LTGIPPAPRGVPQIEVTFALDANGILKVSATDKGTGKSESITITNDKGRLTQEEIDRMVEEAEKF 568

  Fly   549 ADEDKKLKERVESRNELESYAYSLKNQI-GDKDKLGAKLSDDEKNKLESAIDESIKWLEQN-PDA 611
            |.||..:|.:|||||:||:||:|||||: ||   ||.||.:::|..|..|.::.::||:.| ..|
Yeast   569 ASEDASIKAKVESRNKLENYAHSLKNQVNGD---LGEKLEEEDKETLLDAANDVLEWLDDNFETA 630

  Fly   612 DPEEYKKQKKDLEAIVQPVIAKLYQGAGGAPPPEGGDDADLKDE 655
            ..|::.::.:.|..:..|:.:|||.||.|:    |..|.|.:||
Yeast   631 IAEDFDEKFESLSKVAYPITSKLYGGADGS----GAADYDDEDE 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	266/373 (71%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	413/612 (67%)
KAR2	NP_012500.3	HSP70	52..654	CDD:394970	409/605 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	798	1.000	Domainoid score	I4
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3908
Inparanoid	1	1.050	812	1.000	Inparanoid score	I57
Isobase	1	0.950	-	0	Normalized mean entropy	S109
OMA	1	1.010	-	-		QHG53894
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		oto98960
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	LDO	PTHR19375
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R525
SonicParanoid	1	1.000	-	-		X2187
TreeFam	1	0.960	-	-
	15	14.810