DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and ERD2

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_176036.1	Gene:	ERD2 / 842094	AraportID:	AT1G56410	Length:	617	Species:	Arabidopsis thaliana

Alignment Length:	615	Identity:	387/615 - (62%)
Similarity:	482/615 - (78%)	Gaps:	10/615 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93
            |..||||||||||||||:::.||||||||||||.|||||||| |.|||||||||||:..||.|||
plant     7 GPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVAFT-DSERLIGDAAKNQVAMNPVNTV 70

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETA 157
            |||||||||.:||.:||.|:||:||||.. :..||.|.|:.....|.||.||||:|||.||:|.|
plant    71 FDAKRLIGRRFSDASVQSDMKFWPFKVTPGQADKPMIFVNYKGEEKQFAAEEISSMVLIKMREIA 135

  Fly   158 EAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKE---GEKN 219
            |||||..:.:|||||||||||:||||||||||||||.|:||||||||||||||||||.   |.||
plant   136 EAYLGSSIKNAVVTVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKKATSVGIKN 200

  Fly   220 VLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRA 284
            ||:|||||||||||||||:.|:|||.||.|||||||||||.|:::||::.:|:|..|||..|.||
plant   201 VLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHFVQEFKRKNKKDISGDARA 265

  Fly   285 VQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDA 349
            :::||...|:|||.||.:.|..:|::|.|||.||...:|||||||:|:||||..::||.|.|.|:
plant   266 LRRLRTACERAKRTLSSTAQTTVEVDSLFEGIDFYSPITRAKFEEMNMDLFRKCMEPVMKCLRDS 330

  Fly   350 DMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTD 412
            .|:|..||::|||||||||||||||::|||.|||..:.|||||||||||||||.:||||  :...
plant   331 KMDKSMVHDVVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQAAILSGEGNEKVQ 395

  Fly   413 AIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNH 477
            .::||||.||::||||:|||||.||.|||.||.||.|.|:|..|||..|.||||||||..|.||:
plant   396 DLLLLDVTPLSLGIETIGGVMTTLIQRNTTIPAKKEQEFTTTVDNQPDVLIQVYEGERARTIDNN 460

  Fly   478 LLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMI 542
            :||:|.|:|||||||||||..|.|:||:||||.||||||.||.|.||.||||:.||:.:||::|:
plant   461 ILGQFVLSGIPPAPRGIPQFTVCFDIDSNGILNVSAEDKATGKKNKITITNDKGRLSKDDIEKMV 525

  Fly   543 RDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQ 607
            ::|||:..||::.|::||::|.||:|||::.|.:.|   :|.||...:|.|.|.:|:|.|:||:.
plant   526 QEAEKYKSEDEEHKKKVEAKNGLENYAYNVGNTLRD---MGEKLPAADKKKFEDSIEEVIQWLDD 587

  Fly   608 NPDADPEEYKKQKKDLEAIVQPVIAKLYQG 637
            |..|:.:|::.:.|:||::...:|.|:|||
plant   588 NQLAEADEFEHKMKELESVWSTIITKMYQG 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	259/377 (69%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	386/612 (63%)
ERD2	NP_176036.1	PTZ00009	5..617	CDD:240227	385/613 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730