DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-3 and Hsp70b

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_173055.1	Gene:	Hsp70b / 838174	AraportID:	AT1G16030	Length:	646	Species:	Arabidopsis thaliana

Alignment Length:	634	Identity:	399/634 - (62%)
Similarity:	499/634 - (78%)	Gaps:	16/634 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KKEKDKELGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQL 85
            |.||      .||||||||||||||:.|.|||||.||||||.|||||||| |.|||||||||||:
plant     4 KSEK------AIGIDLGTTYSCVGVWMNDRVEIIPNDQGNRTTPSYVAFT-DTERLIGDAAKNQV 61

  Fly    86 TTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPHISVDTSQGAKVFAPEEISAMV 149
            ..||:||||||||||||::||.:||.||..:|||||. ...||.|.|......|.|:|||||:||
plant    62 ALNPQNTVFDAKRLIGRKFSDPSVQSDILHWPFKVVSGPGEKPMIVVSYKNEEKQFSPEEISSMV 126

  Fly   150 LGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDK- 213
            |.||||.|||:||:.|.:|||||||||||:|||||||||.|:||.|:|||||||||||||||||
plant   127 LVKMKEVAEAFLGRTVKNAVVTVPAYFNDSQRQATKDAGAISGLNVLRIINEPTAAAIAYGLDKK 191

  Fly   214 --KEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGK 276
              |.||||||:|||||||||||||||:.|||||.||.|||||||||||.|:::||:..:::|..|
plant   192 GTKAGEKNVLIFDLGGGTFDVSLLTIEEGVFEVKATAGDTHLGGEDFDNRLVNHFVAEFRRKHKK 256

  Fly   277 DIRKDNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKP 341
            ||..:.||:::||...|:|||.||.:.|..|||:|..||.||..|::||:|||:|:||||..:.|
plant   257 DIAGNARALRRLRTACERAKRTLSSTAQTTIEIDSLHEGIDFYATISRARFEEMNMDLFRKCMDP 321

  Fly   342 VQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLS 406
            |:|||:||.::|..||::|||||||||||:|||::|||.|||..:.|||||||||||||||.:|:
plant   322 VEKVLKDAKLDKSSVHDVVLVGGSTRIPKIQQLLQDFFNGKELCKSINPDEAVAYGAAVQAAILT 386

  Fly   407 GE--QDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGE 469
            ||  :....::||||.||::|:||.|||||.||||||.:|.||.|||||.:|||..|.|||||||
plant   387 GEGSEKVQDLLLLDVAPLSLGLETAGGVMTVLIPRNTTVPCKKEQVFSTYADNQPGVLIQVYEGE 451

  Fly   470 RPMTKDNHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLT 534
            |..|:||:|||.|:|.||||||||:|||.|.|:|||||||.||||||..|.|.:|.||||:.||:
plant   452 RARTRDNNLLGTFELKGIPPAPRGVPQINVCFDIDANGILNVSAEDKTAGVKNQITITNDKGRLS 516

  Fly   535 PEDIDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAID 599
            .|:|::|::||||:..||:::|::||::|.||:|||:::|.|.| :||..||:.::|.|:|.|||
plant   517 KEEIEKMVQDAEKYKAEDEQVKKKVEAKNSLENYAYNMRNTIKD-EKLAQKLTQEDKQKIEKAID 580

  Fly   600 ESIKWLEQNPDADPEEYKKQKKDLEAIVQPVIAKLYQG--AGGAPPPEG 646
            |:|:|:|.|..|:.:|::.:.|:||.|..|:|:|:|||  |.|..|.:|
plant   581 ETIEWIEGNQLAEVDEFEYKLKELEGICNPIISKMYQGGAAAGGMPTDG 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	257/377 (68%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	394/618 (64%)
Hsp70b	NP_173055.1	PTZ00009	4..646	CDD:240227	399/634 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730