DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and BIP2

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_001331824.1	Gene:	BIP2 / 834207	AraportID:	AT5G42020	Length:	673	Species:	Arabidopsis thaliana

Alignment Length:	637	Identity:	443/637 - (69%)
Similarity:	531/637 - (83%)	Gaps:	4/637 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KEKDKELGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLT 86
            ||:..:||:|||||||||||||||||||.|||||||||||||||:|.|| |.|||||:|||||..
plant    33 KEEATKLGSVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVGFT-DSERLIGEAAKNQAA 96

  Fly    87 TNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQG-AKVFAPEEISAMVL 150
            .|||.||||.||||||::.|..||.|.|..|:::|.|:.||:|.|....| .|||:|||||||:|
plant    97 VNPERTVFDVKRLIGRKFEDKEVQKDRKLVPYQIVNKDGKPYIQVKIKDGETKVFSPEEISAMIL 161

  Fly   151 GKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKE 215
            .|||||||||||||:..||||||||||||||||||||||||||.|.||||||||||||||||||.
plant   162 TKMKETAEAYLGKKIKDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKKG 226

  Fly   216 GEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRK 280
            ||||:|||||||||||||:||||||||||::|||||||||||||.|:|::||||.|||..|||.|
plant   227 GEKNILVFDLGGGTFDVSVLTIDNGVFEVLSTNGDTHLGGEDFDHRIMEYFIKLIKKKHQKDISK 291

  Fly   281 DNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKV 345
            ||:|:.|||||.|:||||||..||||:||||.|:|.|.||.||||:|||||.||||.|:.||:|.
plant   292 DNKALGKLRRECERAKRALSSQHQVRVEIESLFDGVDLSEPLTRARFEELNNDLFRKTMGPVKKA 356

  Fly   346 LEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE-- 408
            ::||.:.|..:.|||||||||||||||||:||||.||||::|:|||||||||||||.|:||||
plant   357 MDDAGLQKSQIDEIVLVGGSTRIPKVQQLLKDFFEGKEPNKGVNPDEAVAYGAAVQGGILSGEGG 421

  Fly   409 QDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMT 473
            .:|..|:||||.|||:|||||||||||||||||||||||||||:|..|.|.||:|||:||||.:|
plant   422 DETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIQVFEGERSLT 486

  Fly   474 KDNHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDI 538
            ||..|||||||||:||||||.|||||:||:||||||.|.||||.:|..|||.|||::.||:.|:|
plant   487 KDCRLLGKFDLTGVPPAPRGTPQIEVTFEVDANGILNVKAEDKASGKSEKITITNEKGRLSQEEI 551

  Fly   539 DRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIK 603
            |||:::||:||:||||:||::::||.||:|.|::|||:.|||||..||..|||.|:|:|..|:::
plant   552 DRMVKEAEEFAEEDKKVKEKIDARNALETYVYNMKNQVSDKDKLADKLEGDEKEKIEAATKEALE 616

  Fly   604 WLEQNPDADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAPPPEGGDDADLKDE 655
            ||::|.:::.|||.::.|::||:..|:|..:||.:||||...|....:.:||
plant   617 WLDENQNSEKEEYDEKLKEVEAVCNPIITAVYQRSGGAPGAGGESSTEEEDE 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	284/374 (76%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	434/613 (71%)
BIP2	NP_001331824.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	861	1.000	Domainoid score	I4
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3908
Inparanoid	1	1.050	890	1.000	Inparanoid score	I56
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		otm2711
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	LDO	PTHR19375
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840