Protein Alignment Hsc70-3 and Hspa12a

DIOPT Version :9

• Sequence 1: NP_001285139.1
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: XP_006527440.1
• Gene: Hspa12a / 73442
• MGIID: 1920692
• Length: 695
• Species: Mus musculus
• Alignment Length: 666
• Identity: 150/666 - (22%)
• Similarity: 236/666 - (35%)
• Gaps: 223/666 - (33%)

  Fly    31 VIGIDLGTTYS-----------CVGVYKNGRVEIIANDQG--NRITPSYVAFTADGE-RLIGDAA 81
            |:.||.|||.|           |:.|.:...    ..|.|  |:.||:.:..|.:.: ...|.||
Mouse    78 VVAIDFGTTSSGYAYSFTKEPECIHVMRRWE----GGDPGVSNQKTPTTILLTPERKFHSFGYAA 138

  Fly    82 KNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDT----SQGAKVFAP 142
            :        :...|......::|        :....|| ::.::...:::||    :.|.||.|
Mouse   139 R--------DFYHDLDPSEAKQW--------LYLEKFK-MKLHTTGDLTMDTDLTAANGKKVKA- 185

  Fly   143 EEISAMVLGKMKETAEAYLGKKV--------THAVVTVPAYFNDAQRQATKDAGVIAGL------ 193
            .||.|..|...||.|...|..:.        ...|:||||.:....:|..::|...|||
Mouse   186 LEIFAYALQYFKEQALKELSDQAGSDFENSDVRWVITVPAIWKQPAKQFMREAAYQAGLASPENS 250

  Fly   194 QVMRIINEPTAAAI--------------------AYGL--------------------------- 211
            :.:.|..||.||:|                    .|..
Mouse   251 EQLIIALEPEAASIYCRKLRLHQMIELSSKAVVNGYSASDTVGAGFAQAKEHVRRNRQSRTFLVE 315

  Fly   212 --------DKKEGEKNVLVFDLGGGTFDVSL--LTIDNGVFEVV--ATNGDTHLGGEDFDQRVMD 264
                    :.:||:|.|:| |.||||.|:::  :.:..|..:.:  ||.|.....|.|::
Mouse   316 NVIGEIWSELEEGDKYVVV-DSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYE----- 374

  Fly   265 HFIKLYKKKKGKDIRKDNRAVQKLRREV---------EKAKRALSGSHQVRIEIE---SF----- 312
             |.||..|..|:|..:.    .|::|..         |..|||.:......:.|.   ||
Mouse   375 -FEKLLCKIFGEDFIEQ----FKIKRPAAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYK 434

  Fly   313 -FEGD-----------DF----SETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEI-- 359
             |.|.           ||    |:.:.|...:.:|. ||:.|:..:.:.|.|. ..|.:|..:
Mouse   435 KFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNA-LFKPTIDSIIEHLRDL-FQKPEVSTVKF 497

  Fly   360 -VLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAG-VLSGEQDTDAIVLLDVNPL 422
             .||||....|.:||.|:..||.|  .|.|.|.:.   |..:..| ||.|..  .|::.:..:||
Mouse   498 LFLVGGFAEAPLLQQAVQTAFGDK--CRIIIPQDV---GLTILKGAVLFGLD--PAVIKVRRSPL 555

  Fly   423 TMGIETVGGVMTKLI-----PRNTVIP-------------------------TKKSQVFSTASDN 457
            |.|:    ||:.:.:     |...::.                         .|:|  ::.|..:
Mouse   556 TYGV----GVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRS--YTPAKPS 614

  Fly   458 QHTVTIQVYEGER--------PMTKDNHLLGKFDLTG----IPPAPRGIPQIEVSFEIDANGILQ 510
            |..:.|.:|..|.        |..|....| :.||||    ..||.|.|..|....:.:    ::
Mouse   615 QLVIIINIYSSEHDNVSFITDPGVKKCGTL-RLDLTGSGGTAVPARREIQTIMQFGDTE----IK 674

  Fly   511 VSAEDKGTGNKEKIVI 526
            .:|.|..|....|:.|
Mouse   675 ATAVDITTSKSVKVGI 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	114/498 (23%)
		PTZ00009	32..643	CDD:240227	149/665 (22%)
Hspa12a	XP_006527440.1	HSPA12A_like_NBD	77..543	CDD:212685	117/504 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900