Protein Alignment Hsc70-3 and Hspa2

DIOPT Version :9

• Sequence 1: NP_001285139.1
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_068635.1
• Gene: Hspa2 / 60460
• RGDID: 620664
• Length: 633
• Species: Rattus norvegicus
• Alignment Length: 624
• Identity: 390/624 - (62%)
• Similarity: 491/624 - (78%)
• Gaps: 7/624 - (1%)

  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93
            |..||||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||.||:
  Rat     5 GPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNTI 68

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            |||||||||::.|..||.|:|.:||:||.:..||.:.|:.....|.|.|||||:|||.||||.||
  Rat    69 FDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGEMKTFFPEEISSMVLTKMKEIAE 133

  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK---EGEKNV 220
            ||||.||..||:||||||||:|||||||||.|.||.|:||||||||||||||||||   .|||||
  Rat   134 AYLGGKVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNV 198

  Fly   221 LVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAV 285
            |:|||||||||||:|||::|:|||.:|.|||||||||||.|::.|..:.:|:|..|||..:.|||
  Rat   199 LIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAV 263

  Fly   286 QKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDAD 350
            ::||...|:|||.||.|.|..|||:|.:||.||..::|||:|||||.||||.||:||:|.|.||.
  Rat   264 RRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAK 328

  Fly   351 MNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDA 413
            ::|..:.|||||||||||||:|:|::|||.|||.::.|||||||||||||||.:|.|:  ::...
  Rat   329 LDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQD 393

  Fly   414 IVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHL 478
            ::||||.||::||||.|||||.||.|||.||||::|.|:|.||||.:|.:|||||||.|||||:|
  Rat   394 LLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNL 458

  Fly   479 LGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIR 543
            |||||||||||||||:|||||:|:|||||||.|:|.||.||.:.||.||||:.||:.:|||||::
  Rat   459 LGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQ 523

  Fly   544 DAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQN 608
            :|:.:..||:..::||.::|.:|||.|::|..:.| :||..|:|:.:|||:.....|.|.||::|
  Rat   524 EADGYKSEDEANRDRVAAKNAVESYTYNIKQTVED-EKLRGKISEQDKNKILDKCQEVINWLDRN 587

  Fly   609 PDADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAPPPEGG 647
            ..|:.:||:.::|:||.:..|:|:|||||..|.....||
  Rat   588 QMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGGSSGG 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	255/376 (68%)
		PTZ00009	32..643	CDD:240227	387/615 (63%)
Hspa2	NP_068635.1	PTZ00009	2..615	CDD:240227	384/611 (63%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		258/384 (67%)
		HSPA1-2_6-8-like_NBD	7..383	CDD:212675	255/376 (68%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		84/114 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..633		7/14 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730