DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-3 and hspa8

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_001103873.1	Gene:	hspa8 / 573376	ZFINID:	ZDB-GENE-990415-92	Length:	649	Species:	Danio rerio

Alignment Length:	623	Identity:	398/623 - (63%)
Similarity:	501/623 - (80%)	Gaps:	7/623 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93
            |..:|||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||.|||
Zfish     4 GPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNTV 67

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            |||||||||.:.|..||.|:|.:||.|:..||:|.:.|:....:|.|.|||||:|||.||||.||
Zfish    68 FDAKRLIGRRFDDGVVQSDMKHWPFNVINDNSRPKVQVEYKGESKSFYPEEISSMVLTKMKEIAE 132

  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEG-EKNVLV 222
            |||||.|::||:||||||||:|||||||||.|:||.|:||||||||||||||||||.| |:|||:
Zfish   133 AYLGKTVSNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGAERNVLI 197

  Fly   223 FDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQK 287
            |||||||||||:|||::|:|||.:|.|||||||||||.|:::|||..:|:|..|||..:.|||::
Zfish   198 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFITEFKRKHKKDISDNKRAVRR 262

  Fly   288 LRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMN 352
            ||...|:|||.||.|.|..|||:|.:||.||..::|||:|||||.||||.||.||:|.|.||.|:
Zfish   263 LRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKMD 327

  Fly   353 KKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIV 415
            |..:|:||||||||||||:|:|::|:|.|||.::.|||||||||||||||.:|||:  ::...::
Zfish   328 KAQIHDIVLVGGSTRIPKIQKLLQDYFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLL 392

  Fly   416 LLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLG 480
            ||||.||::||||.|||||.||.|||.||||::|.|:|.||||..|.||||||||.|||||:|||
Zfish   393 LLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLG 457

  Fly   481 KFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDA 545
            ||:||||||||||:|||||:|:||||||:.|||.||.||.:.||.||||:.||:.|||:||:::|
Zfish   458 KFELTGIPPAPRGVPQIEVTFDIDANGIMNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEA 522

  Fly   546 EKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPD 610
            ||:..||...:::|.::|.|||||:::|:.:.| :||..|:||::|.|:....:|.|.||::|..
Zfish   523 EKYKAEDDVQRDKVSAKNGLESYAFNMKSTVED-EKLKGKISDEDKQKILDKCNEVIGWLDKNQT 586

  Fly   611 ADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAP--PPEG 646
            |:.||::.|:|:||.:..|:|.||||.|||.|  .|||
Zfish   587 AEREEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPEG 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	256/374 (68%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	394/615 (64%)
hspa8	NP_001103873.1	HSP70	1..614	CDD:331774	391/611 (64%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		260/382 (68%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		84/114 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..649		7/11 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.730