DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-3 and HSPA14

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_057383.2	Gene:	HSPA14 / 51182	HGNCID:	29526	Length:	509	Species:	Homo sapiens

Alignment Length:	506	Identity:	172/506 - (33%)
Similarity:	283/506 - (55%)	Gaps:	15/506 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVFDA 96
            ||:.||.|.:||.|||:||..::|||.|:|:||:.||: ::.|.::|.|||.....|..|||...
Human     4 IGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAY-SENEEIVGLAAKQSRIRNISNTVMKV 67

  Fly    97 KRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYL 161
            |:::||..||...|..|......|:|||.|....:||.:..|...||:::.::..||||||.:.|
Human    68 KQILGRSSSDPQAQKYIAESKCLVIEKNGKLRYEIDTGEETKFVNPEDVARLIFSKMKETAHSVL 132

  Fly   162 GKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGL--DKKEGEKNVLVFD 224
            |......|:|||..|.:.|:.|..:|...||..|:|:|:||:||.:|||:  |...|:.|:|||.
Human   133 GSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLAYGIGQDSPTGKSNILVFK 197

  Fly   225 LGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLR 289
            |||.:..:|::.:::|::.|::||.|.::||..|.:.:..:....:::....|:|.:.||:.||.
Human   198 LGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETLAQYLASEFQRSFKHDVRGNARAMMKLT 262

  Fly   290 REVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKK 354
            ...|.||.:||........::|.:||.||...::||:||.|...||...::.::.:|:.......
Human   263 NSAEVAKHSLSTLGSANCFLDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQNGFTAD 327

  Fly   355 DVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQD---TDAIVL 416
            |::::||.|||:||||:|||:||.|...|....|.|||.:..|||::||:|.|:::   .|::::
Human   328 DINKVVLCGGSSRIPKLQQLIKDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDSLMI 392

  Fly   417 ----LDVNPLTMGIETVGGV-MTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGE-RPMTKD 475
                .|:  |..|::..|.. .|.|.|..|.:|.::..... |..:..:|.:::||.: :...|:
Human   393 ECSARDI--LVKGVDESGASRFTVLFPSGTPLPARRQHTLQ-APGSISSVCLELYESDGKNSAKE 454

  Fly   476 NHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVI 526
            .....:..|..:.....|:..|.....:..:|.|.|:..|:.||..|.|.|
Human   455 ETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	141/372 (38%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	172/506 (34%)
HSPA14	NP_057383.2	HSPA14-like_NBD	2..376	CDD:212680	141/372 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810