Protein Alignment Hsc70-3 and Hsp110

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_001189103.1
• Gene: Hsp110 / 39557
• FlyBaseID: FBgn0026418
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 700
• Identity: 192/700 - (27%)
• Similarity: 334/700 - (47%)
• Gaps: 118/700 - (16%)

  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADG-ERLIGDAAKNQLTTNPENTV 93
            :|||||.|.....|...::|.:|.:|||...|.|||:|||  || :|:||.|||||..||.:|||
  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAF--DGKKRIIGVAAKNQQVTNMKNTV 64

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKV--------FAPEEISAMVL 150
            ...|||:||:::|.:|||::...|.:|..:.       |.|.|.||        |.||:::||:.
  Fly    65 GGFKRLLGRKFNDPHVQHELTSIPARVEARG-------DGSIGIKVNYLGEDQHFGPEQLTAMLF 122

  Fly   151 GKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDK-- 213
            .|:|||:.|.:..:|...|:..|.:|.:|:|:|..||..||||.|:|::||.||.|:|||..|
  Fly   123 TKLKETSAAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKND 187

  Fly   214 --KEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGK 276
              ::..:||:..|.|..:...|......|..:::|:..| .:||.|.|..:.|:|.|.::::...
  Fly   188 LFEDKPRNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKI 251

  Fly   277 DIRKDNRAVQKLRREVEKAKRALS-GSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLK 340
            :.:.:.||..:|..|:||.|:.:| .|.::.:.||.|.:..|.|.::.|::.|||...:.:...:
  Fly   252 NAKTNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQ 316

  Fly   341 PVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVL 405
            ..:::|.::.:...|:|.:.:||||:|||.|:||::..| .|..|..:|.||||:.|||:|..::
  Fly   317 TFKRLLAESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVF-NKPASTTLNQDEAVSRGAALQCAIM 380

  Fly   406 SGEQDTDAIVLLDVNPLTMGI--ETVGGVM---TKLIPRNTVIPTKKSQVFSTASDNQHTVTIQV 465
            |.........:.|:....:.:  ::.|...   .::.|:....|.  |::.:........|:| |
  Fly   381 SPAVRVREFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPF--SRLLTINRKGPFNVSI-V 442

  Fly   466 YEGERPMTKDNHLLGKFDLTGIPPAPRGIPQ-IEVSFEIDANGIL-------------------- 509
            |..:.|.  .:..:|.:.:..:.|..||..| :::...|:.|||:
  Fly   443 YGQQVPY--PDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAA 505

  Fly   510 -QVSAEDK-----------GTGNKEKIVITNDQNR------------------------------ 532
             |.::|:|           ..|.:|......|.|.
  Fly   506 EQAASEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKA 570

  Fly   533 --------------LTPEDIDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQI--GDKDK 581
                          .:|.|:....:...|....|:|..||::::|.||.:.|.::|::  |..::
  Fly   571 SKATELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFER 635

  Fly   582 LGAKLSDDEKNKLESAIDESIKWL-EQNPDADPEEYKKQKKDLEAIVQPV 630
            .   :.:.|:.|:.|.:::...|| |...|.:.:.|..:.:.|.....|:
  Fly   636 Y---VVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	191/697 (27%)
Hsp110	NP_001189103.1	ASKHA_NBD_HSP70_HSPA4_like	4..378	CDD:466826	141/384 (37%)