DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and Hsc70-1

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	375/619 - (60%)
Similarity:	491/619 - (79%)	Gaps:	5/619 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVFDA 96
            :|||||||||||||:::|:|||||||||||.|||||||| :.|||||||||||:..||.||:|||
  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-ESERLIGDAAKNQVAMNPNNTIFDA 70

  Fly    97 KRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYL 161
            ||||||.:.|..||.|:|.:||:|..:|.||.|.|:.....|.|.|||:|:|||.||:|||||||
  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAYL 135

  Fly   162 GKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK-EGEKNVLVFDL 225
            |..||.|||||||||||:|||||||||.||||.|:|||||||||||||||||: ..|:|||:|||
  Fly   136 GGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFDL 200

  Fly   226 GGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRR 290
            ||||||||:|||::|:|||.||.|||||||||||.|:::||::.:::|..||:.::.||:::||.
  Fly   201 GGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLRT 265

  Fly   291 EVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKD 355
            ..|:|||.||.|.|..|||:|.|||.||..::|||:|||||.||||.|::||.|.|.||.|:|..
  Fly   266 ACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKGQ 330

  Fly   356 VHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQD--TDAIVLLD 418
            :|:||||||||||||||:|::|||.|||.::.|||||||||||||||.:|.|::.  ...::|||
  Fly   331 IHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLD 395

  Fly   419 VNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFD 483
            |.||::||||.|||||.||.|||.||||::|:|:|.:|||..|.|||:||||.||:||:.||||:
  Fly   396 VTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKFE 460

  Fly   484 LTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDAEKF 548
            |:.|||||||:||:||:|:|||||||.|:|.:|.||.:.:|.||||:.||:.|||:||:.|||.:
  Fly   461 LSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDAEAY 525

  Fly   549 ADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADP 613
            ...|::.::|:.::|:||||.:.|::.: |.:.|.::.|..::..::....|:|.||:.|..|:.
  Fly   526 RQADEQQRDRINAKNQLESYCFQLRSTL-DDEHLSSRFSPADRETIQQRSSETIAWLDANQLAER 589

  Fly   614 EEYKKQKKDLEAIVQPVIAKLYQGAGGAPPPEGG 647
            :|::.::::||.|..|:|.:||||||.||||..|
  Fly   590 QEFEHKQQELERICSPIITRLYQGAGMAPPPTAG 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	252/371 (68%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	371/613 (61%)
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	375/619 (61%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	253/374 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464238
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.750