Protein Alignment Hsc70-3 and hspa4

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_989252.1
• Gene: hspa4 / 394863
• XenbaseID: XB-GENE-952769
• Length: 835
• Species: Xenopus tropicalis
• Alignment Length: 692
• Identity: 196/692 - (28%)
• Similarity: 339/692 - (48%)
• Gaps: 102/692 - (14%)

  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            :|:|.|||.....|.|.:.|.:|.:||:..:|.||:.::| ....|.||.|||:|:.:|.:||:.
 Frog     2 SVVGFDLGFLSCYVAVARAGGIETVANEYSDRSTPACISF-GPKNRSIGAAAKSQVISNAKNTLQ 65

  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            ..||..||.::|..||.:.....|::|| ......|.|...:..:.|..|:::||.|.|:|||||
 Frog    66 GFKRFHGRAYTDPFVQAEKPGLAFELVELPTGSAGIKVVYLEEERSFTIEQVTAMQLTKLKETAE 130

  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK-----EGEK 218
            :.|.|.|...||.||::|.||:|::..||..||||..:|:|||.||.|:|||:.|:     |.:.
 Frog   131 SALKKPVVDCVVAVPSFFTDAERRSVVDATQIAGLNCLRLINETTAVALAYGIYKQDLPAPEEKP 195

  Fly   219 NVLVF-DLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDN 282
            .::|| |:|...:.||:...:.|..:|:||:.|..|||..||..::::|::.:.||...||:...
 Frog   196 RIVVFADMGHSAYQVSVCAFNKGKLKVLATSFDPTLGGRKFDDVLVNYFVEEFGKKYKLDIKSKI 260

  Fly   283 RAVQKLRREVEKAKRALS-GSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVL 346
            |.:.:|.:|.||.|:.:| .:.::.:.||.|....|.:.::.|..|||:...|......|::.||
 Frog   261 RPLLRLAQECEKLKKLMSANASELPLNIECFMNDIDVTGSMNRGHFEEMCDSLLSRVEPPLRSVL 325

  Fly   347 EDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDT 411
            |.|.:.|:|::.:.:|||:||||.|::.:..|| |||.|..:|.|||||.|.|:|..:||.....
 Frog   326 EQAKLKKEDIYAVEIVGGATRIPAVKERIMRFF-GKEVSTTLNADEAVARGCALQCAILSPAFKV 389

  Fly   412 DAIVLLDVNPLTMGIE-----TVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQV-YEGER 470
            ....:.|:.|..:.::     ..|....::.|:|...|..|...|.    .:.:..:.. |...:
 Frog   390 REFSITDLVPYPISLKWNSPAEEGLSDCEVFPKNHAAPFSKVLTFY----RKESFNLDAYYSAPK 450

  Fly   471 PMTKDNHLLGKFDLTG-IPPAPRGIPQIEVSFEIDANGILQVSA-----------------EDKG 517
            .:...:..||:|.:.. ||.|.....:::|...::.:||..||:                 .|:.
 Frog   451 ELPYPDPSLGQFHIQKVIPQADGSSSKVKVKVRVNIHGIFSVSSASLVEIHKTEDGEEPMETDQV 515

  Fly   518 TGNKEKIVITNDQNRLTPED--------------------------------------------- 537
            |..:||:.:  ||....||:
 Frog   516 TKEEEKMQV--DQEEAKPEENQQAESKTNPDEMETSQPGTKDKKTDQPPQAKKAKVKTSTVDLPI 578

  Fly   538 ------------IDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQI-GDKDKLGAKLSDD 589
                        ::..:.:..|...:||..|||.:::|.:|.|.|.::::: |..:|.   :|:|
 Frog   579 EHYPPWQIGRDMLNLFVENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGIYEKF---VSED 640

  Fly   590 EKNKLESAIDESIKWLEQNPDADPEE-YKKQKKDLEAIVQPV 630
            ::|.....::::..||.::.:..|:: |..:..||:.:..|:
 Frog   641 DRNSFILKLEDTENWLYEDGEDQPKQVYIDKLNDLKKLGNPI 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	195/690 (28%)
hspa4	NP_989252.1	ASKHA_NBD_HSP70_HSPA4	2..382	CDD:466843	144/381 (38%)