DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and CG7182

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	120/499 - (24%)
Similarity:	231/499 - (46%)	Gaps:	33/499 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GIDLGTTYSCVG-VYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVFDA 96
            ||.:|.:..|:. |..:|:.|:|||.||:|::.:.:.:....|...|..||.::...|...|..:
  Fly     6 GIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVAHS 70

  Fly    97 KRLI--GREWSDTNVQHDIKFFP---------FKVVEKNSKPHISVDTSQGAKVFAPEEISAMVL 150
            .:|:  ..|.::..:...::..|         |::...........|.....|..:..:::..:|
  Fly    71 FQLLQPKEELTEEKLSSALREIPCDFDKEELVFRMEHTVPSDREDQDDRVVTKDLSAYQVTVELL 135

  Fly   151 GKMKETAEAYL--GKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAY--GL 211
            ....|.|..|.  |::...||:::|:|:..:..:...||...||..|.:||.|||||.:.|  |.
  Fly   136 RAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEPTAAVLGYSIGE 200

  Fly   212 DKKEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGK 276
            ::.|..::||....||...|::..::.||:|..:||.|...:||..|.:.::....:.:::|...
  Fly   201 EQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQFTEALVQFICEEFRRKYKL 265

  Fly   277 DIRKDNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKP 341
            |..:..|:|.|:|......|..|:.....::.|:|..:|.|::..::||:||.|...:..:.::.
  Fly   266 DPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNAQMSRARFESLIQPVINNLIQQ 330

  Fly   342 VQKVLEDAD-----MNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQ 401
            :.:.:|.|.     ::|.|  :|||:|.:.:|||:|..|...|...:.....:.||.||.|.|.|
  Fly   331 LGECVEQAQKEHPGLSKID--DIVLLGATMQIPKLQAAVGARFPDAKLHNSHSADEVVAIGCARQ 393

  Fly   402 AGVLSG------EQDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHT 460
            |..|..      .::.|.:|..|...:..|.:.....:  ::.|.:|:|.|.......:.:.:..
  Fly   394 AVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKL--VLGRGSVLPAKIRISLPQSEEGKGD 456

  Fly   461 VTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIPQIEVSFEID 504
            ...:.....:..|.::.:|.:...:.||  ..|:.|:||..::|
  Fly   457 DVSKAAASFKLRTGESEILARLPDSTIP--EDGLYQLEVEVDVD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	101/390 (26%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	120/499 (24%)
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	100/389 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464193
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840