Protein Alignment Hsc70-3 and hspa5

DIOPT Version :9

• Sequence 1: NP_001285139.1
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_998223.1
• Gene: hspa5 / 378848
• ZFINID: ZDB-GENE-031001-11
• Length: 650
• Species: Danio rerio
• Alignment Length: 655
• Identity: 529/655 - (80%)
• Similarity: 591/655 - (90%)
• Gaps: 9/655 - (1%)

  Fly     3 LCILLAVVAFVGLSLGEEKKEKDKELGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYV 67
            ||:.|.|..    |:..|:.:|.:.:|||||||||||||||||||||||||||||||||||||||
Zfish     4 LCLFLLVAG----SVFAEEDDKKESVGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYV 64

  Fly    68 AFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVD 132
            |||.:||||||||||||||:|||||||||||||||.|.|::||.|||:|||||:||.:||||.:|
Zfish    65 AFTTEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWGDSSVQQDIKYFPFKVIEKKNKPHIQLD 129

  Fly   133 TSQG-AKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVM 196
            ...| .|.|||||||||||.|||||||||||||||||||||||||||||||||||||.||||.||
Zfish   130 IGSGQMKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVM 194

  Fly   197 RIINEPTAAAIAYGLDKKEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQR 261
            |||||||||||||||||::||||:|||||||||||||||||||||||||||||||||||||||||
Zfish   195 RIINEPTAAAIAYGLDKRDGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQR 259

  Fly   262 VMDHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAK 326
            ||:|||||||||.|||:||||||||||||||||||||||..||.||||||||||:||||||||||
Zfish   260 VMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSAQHQARIEIESFFEGEDFSETLTRAK 324

  Fly   327 FEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPD 391
            |||||:||||||:|||||||||:|..|.|:.|||||||||||||:|||||:||.|||||||||||
Zfish   325 FEELNMDLFRSTMKPVQKVLEDSDPKKPDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPD 389

  Fly   392 EAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASD 456
            |||||||||||||||||::|..:|||||.|||:||||||||||||||||||:||||||:||||||
Zfish   390 EAVAYGAAVQAGVLSGEEETGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASD 454

  Fly   457 NQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNK 521
            ||.||||:|||||||:||||||||.||||||||||||:|||||:||||.||||:|:|||||||||
Zfish   455 NQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNK 519

  Fly   522 EKIVITNDQNRLTPEDIDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKL 586
            .||.|||||||||||||:||:.:||:|||||||||||::|||||||||||||||||||:|||.||
Zfish   520 NKITITNDQNRLTPEDIERMVNEAERFADEDKKLKERIDSRNELESYAYSLKNQIGDKEKLGGKL 584

  Fly   587 SDDEKNKLESAIDESIKWLEQNPDADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAPPPEGGDDAD 651
            |.::|..:|.|::|.|:|||.:.|||.||::.:||:||.:|||:::|||..||| ||||   :|:
Zfish   585 SSEDKEAIEKAVEEKIEWLEAHQDADLEEFQAKKKELEEVVQPIVSKLYGSAGG-PPPE---EAE 645

  Fly   652 LKDEL 656
            .||||
Zfish   646 EKDEL 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	330/374 (88%)
		PTZ00009	32..643	CDD:240227	510/611 (83%)
hspa5	NP_998223.1	HSPA5-like_NBD	26..401	CDD:212681	330/374 (88%)
		PTZ00009	29..641	CDD:240227	511/612 (83%)
		Periplasmic_Binding_Protein_Type_2	<583..640	CDD:304360	29/57 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581268
Domainoid	1	1.000	1020	1.000	Domainoid score	I27
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3908
Inparanoid	1	1.050	1058	1.000	Inparanoid score	I246
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D237853at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		oto41366
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	LDO	PTHR19375
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R525
SonicParanoid	1	1.000	-	-		X2187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940