DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and hspa4b

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_956151.1	Gene:	hspa4b / 334086	ZFINID:	ZDB-GENE-030131-6018	Length:	840	Species:	Danio rerio

Alignment Length:	717	Identity:	201/717 - (28%)
Similarity:	336/717 - (46%)	Gaps:	147/717 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            :|:|.|:|.....|.|.:.|.:|.:||:..:|.||:.|:| ....|.||.|||:|:.||.:|||.
Zfish     2 SVVGFDVGFLNCYVAVARAGGIETVANEYSDRCTPACVSF-GPRNRSIGAAAKSQMVTNCKNTVH 65

  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQ--------------GAKVFAPEEI 145
            ..||..||.:||..||             |.||.:..|.:|              ..|||:.|::
Zfish    66 GFKRFHGRAFSDPFVQ-------------NLKPSLVYDLAQMPSGTTGLKVMYMEEEKVFSIEQV 117

  Fly   146 SAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYG 210
            :||:|.|:|||||:.|.|.|...|::||.::.||:|::..||..||||..:|::||.||.|:|||
Zfish   118 TAMLLTKLKETAESALKKPVADCVISVPCFYTDAERRSVIDAAQIAGLNCLRLMNETTAVALAYG 182

  Fly   211 LDK------KEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKL 269
            :.|      :|..:||:..|:|...:.||:...:.|..:::||..|..:||:.||:|::.:|.:.
Zfish   183 IYKQDLPAPEEKPRNVVFVDIGHSGYQVSVCAFNKGKLKILATAFDPEMGGKYFDERLVKYFCEE 247

  Fly   270 YKKKKGKDIRKDNRAVQKLRREVEKAKRALS-GSHQVRIEIESFFEGDDFSETLTRAKFEELNLD 333
            :..|...|.:...||:.:|.:|.||.|:.:| .|..:.:.||.|....|.|..|.||:|||:..|
Zfish   248 FVVKYKLDAKTKPRALIRLFQECEKLKKLMSANSSDLPLNIECFMNDVDVSSRLNRAQFEEMCAD 312

  Fly   334 LFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGA 398
            :......|::.:||.|.:.|.|:|.:.:|||::|:|.:::.:..|| |||||..:|.|||||.|.
Zfish   313 ILARVEPPLRSLLEQAHLKKDDIHAVEIVGGASRMPAIKERISKFF-GKEPSTTLNADEAVARGC 376

  Fly   399 AVQAGVLSGEQDTDAIVLLDVNPLTMGIE----TVGGVM-TKLIPRNTVIPTKKSQVFSTASDNQ 458
            |:|..:||.........:.:|.|..:.::    ...||. .::.|:|...|..|...|.    .:
Zfish   377 ALQCAILSPAFKVREFSITEVVPFPISLKWNSAAEDGVSDCEVFPKNHAAPFSKVLTFY----RR 437

  Fly   459 HTVTIQV-YEGERPMTKDNHLLGKFDLTGIPPAPRG-IPQIEVSFEIDANGILQVSA-------- 513
            ...|:.. |...:.:...:..:|::.:..:.|...| ..:::|...::.:||..||:
Zfish   438 EPFTLDAYYNSPKELPYPDPTIGQYVVQKVVPQASGESSKVKVKVRVNIHGIFSVSSASLVEVQK 502

  Fly   514 ------------------EDK----------------------GT---------GNKEK------ 523
                              |:|                      ||         |.:||
Zfish   503 SEEEEESMETEQSTEKENENKMQVDQEEQKTPETEQENGEKKPGTEEMETSAEEGKQEKKSDQPP 567

  Fly   524 --------------IVITNDQNRLTPEDIDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKN 574
                          .:..|.|.:|..:.::..:....|...:||..|||.:::|.:|.|.|.:::
Zfish   568 QAKKPKVKTKVLDLPIENNPQWQLANDMLNLFVESEGKMIMQDKLEKERNDAKNYVEEYVYEMRD 632

  Fly   575 QI----------GDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADPEE-YKKQKKDLEAIVQ 628
            ::          .|:|.|..||.|.|            .||.::.:..|:: |..:..:|:.:.|
Zfish   633 KLHGIFEKFVTESDRDVLSLKLEDTE------------VWLYEDGEDQPKQIYIDKLAELKNLGQ 685

  Fly   629 PV 630
            |:
Zfish   686 PI 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	146/393 (37%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	200/715 (28%)
hspa4b	NP_956151.1	HSPA4_NBD	2..384	CDD:212687	146/396 (37%)
hspa4b	NP_956151.1	HSP70	3..693	CDD:278441	201/716 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900