DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and HSPA9

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_004125.3	Gene:	HSPA9 / 3313	HGNCID:	5244	Length:	679	Species:	Homo sapiens

Alignment Length:	647	Identity:	331/647 - (51%)
Similarity:	436/647 - (67%)	Gaps:	42/647 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93
            |.|:|||||||.|||.|.:..:.:::.|.:|.|.|||.||||||||||:|..||.|..|||.||.
Human    53 GAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTF 117

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNS-----KPHISVDTSQGAKVFAPEEISAMVLGKM 153
            :..||||||.:.|..||.|||..|||:|..::     :.|        .|:::|.:|.|.||.||
Human   118 YATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAH--------GKLYSPSQIGAFVLMKM 174

  Fly   154 KETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEGEK 218
            |||||.|||....:||:||||||||:|||||||||.|:||.|:|:||||||||:||||||.| :|
Human   175 KETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSE-DK 238

  Fly   219 NVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNR 283
            .:.|:||||||||:|:|.|..|||||.:|||||.||||||||.::.|.:|.:|::.|.|:.|||.
Human   239 VIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNM 303

  Fly   284 AVQKLRREVEKAKRALSGSHQVRIEIESFFEGDD-----FSETLTRAKFEELNLDLFRSTLKPVQ 343
            |:|::|...||||..||.|.|..|.: .:...|.     .:..||||:||.:..||.|.|:.|.|
Human   304 ALQRVREAAEKAKCELSSSVQTDINL-PYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQ 367

  Fly   344 KVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE 408
            |.::||:::|.|:.|::||||.||:|||||.|:|.| |:.||:.:|||||||.|||:|.|||:|
Human   368 KAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAG- 430

  Fly   409 QDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMT 473
             |...::||||.||::||||:|||.||||.|||.||||||||||||:|.|..|.|:|.:|||.|.
Human   431 -DVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMA 494

  Fly   474 KDNHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDI 538
            .||.|||:|.|.||||||||:|||||:|:||||||:.|||:|||||.:::||| .....|:.:||
Human   495 GDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVI-QSSGGLSKDDI 558

  Fly   539 DRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGD-KDKLGAKLSDDEKNKLESAIDESI 602
            :.|:::|||:|:||::.|||||:.|..|...:..:.::.: ||:|.|    ||.|||:..|.:..
Human   559 ENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA----DECNKLKEEISKMR 619

  Fly   603 KWLEQNPDADPEEYKKQKKDLEAIVQPVIAKLYQGA---------GGAPPPEGGDDADLKDE 655
            :.|.:......|..::....|    |....||::.|         |......|....|.|:|
Human   620 ELLARKDSETGENIRQAASSL----QQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEE 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	208/383 (54%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	325/630 (52%)
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269\|PubMed:26702583	1..432		212/391 (54%)
		dnaK	52..673	CDD:234715	328/641 (51%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269\|PubMed:26702583	432..679		118/255 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	656..679		5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D237853at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820