DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and HSPA6

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_002146.2	Gene:	HSPA6 / 3310	HGNCID:	5239	Length:	643	Species:	Homo sapiens

Alignment Length:	617	Identity:	376/617 - (60%)
Similarity:	489/617 - (79%)	Gaps:	7/617 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KELGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPE 90
            :||  .:|||||||||||||::.|||||:|||||||.|||||||| |.|||:|||||:|...||.
Human     5 REL--AVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFT-DTERLVGDAAKSQAALNPH 66

  Fly    91 NTVFDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKE 155
            ||||||||||||:::||.||.|:|.:||:||.:..||.:.|......|.|.|||||:|||.||||
Human    67 NTVFDAKRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKE 131

  Fly   156 TAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK-EGEKN 219
            |||||||:.|.|||:||||||||:|||||||||.||||.|:||||||||||||||||:: .||:|
Human   132 TAEAYLGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERN 196

  Fly   220 VLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRA 284
            ||:|||||||||||:|:||.|||||.||.|||||||||||.|:::||::.:::|.|||:..:.||
Human   197 VLIFDLGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRA 261

  Fly   285 VQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDA 349
            :::||...|:|||.||.|.|..:||:|.|||.||..::|||:||||..|||||||:||:|.|.||
Human   262 LRRLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDA 326

  Fly   350 DMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTD 412
            .::|..:|::|||||||||||||:|::|||.|||.::.|||||||||||||||.||.|:  :...
Human   327 KLDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQ 391

  Fly   413 AIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNH 477
            .::||||.||::|:||.|||||.||.||..||||::|.|:|.||||..|.||||||||.|||||:
Human   392 DLLLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNN 456

  Fly   478 LLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMI 542
            |||:|:|:||||||||:|||||:|:|||||||.|:|.|:.||...||.||||:.||:.|:::||:
Human   457 LLGRFELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMV 521

  Fly   543 RDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQ 607
            .:||::..||:..::||.::|.||::.:.:|..: .::.|..|:.::::.|::....|.:.|||.
Human   522 HEAEQYKAEDEAQRDRVAAKNSLEAHVFHVKGSL-QEESLRDKIPEEDRRKMQDKCREVLAWLEH 585

  Fly   608 NPDADPEEYKKQKKDLEAIVQPVIAKLYQGAG 639
            |..|:.|||:.||::||.|.:|:.::||.|.|
Human   586 NQLAEKEEYEHQKRELEQICRPIFSRLYGGPG 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	253/374 (68%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	374/611 (61%)
HSPA6	NP_002146.2	Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	3..388		259/385 (67%)
		HSP70	8..643	CDD:331774	374/612 (61%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	396..511		79/114 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..643		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730