| Sequence 1: | NP_001285139.1 | Gene: | Hsc70-3 / 32133 | FlyBaseID: | FBgn0001218 | Length: | 656 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_005338.1 | Gene: | HSPA5 / 3309 | HGNCID: | 5238 | Length: | 654 | Species: | Homo sapiens |
| Alignment Length: | 657 | Identity: | 529/657 - (80%) |
|---|---|---|---|
| Similarity: | 594/657 - (90%) | Gaps: | 4/657 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1 MKLCILLAVVAFVGLSLGEEKKEKDKELGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPS 65
Fly 66 YVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHIS 130
Fly 131 VDTSQG-AKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQ 194
Fly 195 VMRIINEPTAAAIAYGLDKKEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFD 259
Fly 260 QRVMDHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTR 324
Fly 325 AKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGIN 389
Fly 390 PDEAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTA 454
Fly 455 SDNQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTG 519
Fly 520 NKEKIVITNDQNRLTPEDIDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGA 584
Fly 585 KLSDDEKNKLESAIDESIKWLEQNPDADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAPPPEGGDD 649
Fly 650 ADLKDEL 656 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Hsc70-3 | NP_001285139.1 | HSPA5-like_NBD | 29..403 | CDD:212681 | 329/374 (88%) |
| PTZ00009 | 32..643 | CDD:240227 | 510/611 (83%) | ||
| HSPA5 | NP_005338.1 | Required for interaction with KIAA1324. /evidence=ECO:0000269|PubMed:26045166 | 1..80 | 54/79 (68%) | |
| HSP70 | 30..635 | CDD:394970 | 507/604 (84%) | ||
| Nucleotide-binding (NBD). /evidence=ECO:0000303|PubMed:28286085 | 125..280 | 138/154 (90%) | |||
| Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 | 409..419 | 6/9 (67%) | |||
| Substrate-binding (SBD). /evidence=ECO:0000303|PubMed:28286085 | 420..500 | 70/79 (89%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 633..654 | 12/22 (55%) | |||
| Prevents secretion from ER. /evidence=ECO:0000255 | 651..654 | 2/2 (100%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165147529 | |
| Domainoid | 1 | 1.000 | 1012 | 1.000 | Domainoid score | I27 |
| eggNOG | 1 | 0.900 | - | - | E1_COG0443 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H3908 | |
| Inparanoid | 1 | 1.050 | 1061 | 1.000 | Inparanoid score | I257 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S109 |
| OMA | 1 | 1.010 | - | - | QHG53894 | |
| OrthoDB | 1 | 1.010 | - | - | D237853at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000049 | |
| OrthoInspector | 1 | 1.000 | - | - | oto88367 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100083 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR19375 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R525 |
| SonicParanoid | 1 | 1.000 | - | - | X2187 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 18 | 17.750 | |||||