DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-3 and HSPA4

DIOPT Version :10

Sequence 1:NP_511132.2 Gene:Hsc70-3 / 32133 FlyBaseID:FBgn0001218 Length:656 Species:Drosophila melanogaster
Sequence 2:NP_002145.3 Gene:HSPA4 / 3308 HGNCID:5237 Length:840 Species:Homo sapiens


Alignment Length:706 Identity:204/706 - (28%)
Similarity:341/706 - (48%) Gaps:127/706 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            :|:|||||.....|.|.:.|.:|.|||:..:|.||:.::| ....|.||.|||:|:.:|.:|||.
Human     2 SVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISF-GPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQ------GAKV--------FAPEEI 145
            ..||..||.:||          ||...||:   :::.|..|      |.||        |..|::
Human    66 GFKRFHGRAFSD----------PFVEAEKS---NLAYDIVQLPTGLTGIKVTYMEEERNFTTEQV 117

  Fly   146 SAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYG 210
            :||:|.|:|||||:.|.|.|...||:||.::.||:|::..||..||||..:|::||.||.|:|||
Human   118 TAMLLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYG 182

  Fly   211 LDK------KEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKL 269
            :.|      :|..:||:..|:|...:.||:...:.|..:|:||..||.|||..||:.:::||.:.
Human   183 IYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEE 247

  Fly   270 YKKKKGKDIRKDNRAVQKLRREVEKAKRALS-GSHQVRIEIESFFEGDDFSETLTRAKFEELNLD 333
            :.||...||:...||:.:|.:|.||.|:.:| .:..:.:.||.|....|.|.|:.|.||.|:..|
Human   248 FGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCND 312

  Fly   334 LFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGA 398
            |......|::.|||...:.|:|::.:.:|||:||||.|::.:..|| |||.|..:|.||||..|.
Human   313 LLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGC 376

  Fly   399 AVQAGVLSGEQDTDAIVLLDVNPLTMGIE-----TVGGVMTKLIPRNTVIPTKKSQVFSTASDNQ 458
            |:|..:||.........:.||.|..:.:.     ..|....::..:|...|..|...|.    .:
Human   377 ALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTFY----RK 437

  Fly   459 HTVTIQV-YEGERPMTKDNHLLGKFDLTGIPPAPRG-IPQIEVSFEIDANGILQVSA-------- 513
            ...|::. |...:.:...:..:.:|.:..:.|...| ..:::|...::.:||..||:        
Human   438 EPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHK 502

  Fly   514 ---------EDKGTGNKEKIVI------TNDQNRLTPED-------------------------- 537
                     .|:....:||:.:      ..:|.:.||.:                          
Human   503 SEENEEPMETDQNAKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQA 567

  Fly   538 ---------------------IDR-----MIRDAEKFADEDKKLKERVESRNELESYAYSLKNQI 576
                                 |||     .|.:..|...:||..|||.:::|.:|.|.|.:::::
Human   568 KKAKVKTSTVDLPIENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKL 632

  Fly   577 -GDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADPEE-YKKQKKDLEAIVQPV 630
             |:.:|.   :|:|::|.....::::..||.::.:..|:: |..:..:|:.:.||:
Human   633 SGEYEKF---VSEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPI 685

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-3NP_511132.2 PTZ00009 32..643 CDD:240227 203/704 (29%)
HSPA4NP_002145.3 ASKHA_NBD_HSP70_HSPA4 2..382 CDD:466843 152/394 (39%)
PTZ00121 <499..743 CDD:173412 32/190 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..575 6/74 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 779..840
Blue background indicates that the domain is not in the aligned region.

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