DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-3 and HSPA4

DIOPT Version :9

Sequence 1:NP_001285139.1 Gene:Hsc70-3 / 32133 FlyBaseID:FBgn0001218 Length:656 Species:Drosophila melanogaster
Sequence 2:NP_002145.3 Gene:HSPA4 / 3308 HGNCID:5237 Length:840 Species:Homo sapiens


Alignment Length:706 Identity:204/706 - (28%)
Similarity:341/706 - (48%) Gaps:127/706 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            :|:|||||.....|.|.:.|.:|.|||:..:|.||:.::| ....|.||.|||:|:.:|.:|||.
Human     2 SVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISF-GPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQ------GAKV--------FAPEEI 145
            ..||..||.:||          ||...||:   :::.|..|      |.||        |..|::
Human    66 GFKRFHGRAFSD----------PFVEAEKS---NLAYDIVQLPTGLTGIKVTYMEEERNFTTEQV 117

  Fly   146 SAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYG 210
            :||:|.|:|||||:.|.|.|...||:||.::.||:|::..||..||||..:|::||.||.|:|||
Human   118 TAMLLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYG 182

  Fly   211 LDK------KEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKL 269
            :.|      :|..:||:..|:|...:.||:...:.|..:|:||..||.|||..||:.:::||.:.
Human   183 IYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEE 247

  Fly   270 YKKKKGKDIRKDNRAVQKLRREVEKAKRALS-GSHQVRIEIESFFEGDDFSETLTRAKFEELNLD 333
            :.||...||:...||:.:|.:|.||.|:.:| .:..:.:.||.|....|.|.|:.|.||.|:..|
Human   248 FGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCND 312

  Fly   334 LFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGA 398
            |......|::.|||...:.|:|::.:.:|||:||||.|::.:..|| |||.|..:|.||||..|.
Human   313 LLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGC 376

  Fly   399 AVQAGVLSGEQDTDAIVLLDVNPLTMGIE-----TVGGVMTKLIPRNTVIPTKKSQVFSTASDNQ 458
            |:|..:||.........:.||.|..:.:.     ..|....::..:|...|..|...|.    .:
Human   377 ALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTFY----RK 437

  Fly   459 HTVTIQV-YEGERPMTKDNHLLGKFDLTGIPPAPRG-IPQIEVSFEIDANGILQVSA-------- 513
            ...|::. |...:.:...:..:.:|.:..:.|...| ..:::|...::.:||..||:        
Human   438 EPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHK 502

  Fly   514 ---------EDKGTGNKEKIVI------TNDQNRLTPED-------------------------- 537
                     .|:....:||:.:      ..:|.:.||.:                          
Human   503 SEENEEPMETDQNAKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQA 567

  Fly   538 ---------------------IDR-----MIRDAEKFADEDKKLKERVESRNELESYAYSLKNQI 576
                                 |||     .|.:..|...:||..|||.:::|.:|.|.|.:::::
Human   568 KKAKVKTSTVDLPIENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKL 632

  Fly   577 -GDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADPEE-YKKQKKDLEAIVQPV 630
             |:.:|.   :|:|::|.....::::..||.::.:..|:: |..:..:|:.:.||:
Human   633 SGEYEKF---VSEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPI 685

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-3NP_001285139.1 HSPA5-like_NBD 29..403 CDD:212681 152/393 (39%)
PTZ00009 32..643 CDD:240227 203/704 (29%)
HSPA4NP_002145.3 HSPA4_NBD 2..384 CDD:212687 152/396 (38%)
HSP70 3..607 CDD:278441 183/622 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..575 6/74 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 779..840
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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