DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and HSPA1A

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_005336.3	Gene:	HSPA1A / 3303	HGNCID:	5232	Length:	641	Species:	Homo sapiens

Alignment Length:	626	Identity:	388/626 - (61%)
Similarity:	500/626 - (79%)	Gaps:	12/626 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVFDA 96
            ||||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||:||||||
Human     7 IGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVALNPQNTVFDA 70

  Fly    97 KRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYL 161
            ||||||::.|..||.|:|.:||:|:....||.:.|......|.|.|||||:|||.||||.|||||
Human    71 KRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYL 135

  Fly   162 GKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK-EGEKNVLVFDL 225
            |..||:||:||||||||:||||||||||||||.|:||||||||||||||||:. :||:|||:|||
Human   136 GYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDL 200

  Fly   226 GGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRR 290
            ||||||||:||||:|:|||.||.|||||||||||.|:::||::.:|:|..|||.::.|||::||.
Human   201 GGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRT 265

  Fly   291 EVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKD 355
            ..|:|||.||.|.|..:||:|.|||.||..::|||:||||..|||||||:||:|.|.||.::|..
Human   266 ACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQ 330

  Fly   356 VHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIVLLD 418
            :|::|||||||||||||:|::|||.|::.::.|||||||||||||||.:|.|:  ::...::|||
Human   331 IHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLD 395

  Fly   419 VNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFD 483
            |.||::|:||.|||||.||.||:.||||::|:|:|.||||..|.||||||||.|||||:|||:|:
Human   396 VAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFE 460

  Fly   484 LTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDAEKF 548
            |:||||||||:|||||:|:|||||||.|:|.||.||...||.||||:.||:.|:|:||:::|||:
Human   461 LSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKY 525

  Fly   549 ADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADP 613
            ..||:..:|||.::|.|||||:::|:.:.| :.|..|:|:.:|.|:.....|.|.||:.|..|:.
Human   526 KAEDEVQRERVSAKNALESYAFNMKSAVED-EGLKGKISEADKKKVLDKCQEVISWLDANTLAEK 589

  Fly   614 EEYKKQKKDLEAIVQPVIAKLYQGAGGAPP-------PEGG 647
            :|::.::|:||.:..|:|:.|||||||..|       |:||
Human   590 DEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGG 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	254/371 (68%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	384/613 (63%)
HSPA1A	NP_005336.3	PTZ00009	1..611	CDD:240227	377/605 (62%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		257/379 (68%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		80/114 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..641		7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730