DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-3 and Hspa14

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_001004257.1	Gene:	Hspa14 / 307133	RGDID:	1303296	Length:	509	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	177/508 - (34%)
Similarity:	287/508 - (56%)	Gaps:	19/508 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVFDA 96
            ||:.||.|.:||.|||:||.:::|||.|:|:||:.||: ::.|:::|.|||.....|..:||...
  Rat     4 IGVHLGCTSACVAVYKDGRADVVANDAGDRVTPAVVAY-SEREQVVGLAAKQSRIRNISSTVVKV 67

  Fly    97 KRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYL 161
            |:::||..:|...|..|......|:|||.|....:||.:..|:.:||:::.::..||||||.:.|
  Rat    68 KQILGRSTADPQAQKYISESKCLVIEKNGKLQYEIDTGEETKLVSPEDVARLIFSKMKETAHSVL 132

  Fly   162 GKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGL--DKKEGEKNVLVFD 224
            |......|||||..|.:.|:.|..:|...||..|:|:|:||:||.:|||:  |...|:.|||||.
  Rat   133 GSDANDVVVTVPFDFGEKQKSALGEAAGAAGFNVLRLIHEPSAALLAYGIGQDCPTGKSNVLVFK 197

  Fly   225 LGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFD----QRVMDHFIKLYKKKKGKDIRKDNRAV 285
            |||.:..:|::.:::|::.|::||...::||..|.    |.:...|.:|:|    .|:|...||:
  Rat   198 LGGTSLSLSIMEVNSGMYRVLSTNTSDNIGGVHFTDSLAQYLASEFQRLFK----HDVRGSARAM 258

  Fly   286 QKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDAD 350
            .||....|.||.:||........::|.:||.||...::||:||.|...||...::.|:.:|:.:.
  Rat   259 MKLMNSAEVAKHSLSTLGSANCFVDSLYEGQDFDCNVSRARFELLCSPLFNKCIEAVRALLQQSG 323

  Fly   351 MNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDT--DA 413
            ....|::::||.|||:|||::|||:||.|...:....|.|||.:..|||::||:|.|::.|  |.
  Rat   324 FTADDINKVVLCGGSSRIPRLQQLIKDLFPAGDLLNSIPPDEVIPIGAAIEAGILVGKESTSGDD 388

  Fly   414 IVLLDVNP---LTMGIETVG-GVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGE-RPMT 473
            .||::.:.   |..|::..| ...|.|.|..|.:|.::..... |..:..:|.:::||.| :...
  Rat   389 SVLIECSARDILVKGVDESGANRFTVLFPSGTPLPARRQHTLQ-APGSISSVCLELYESEGKNSV 452

  Fly   474 KDNHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVI 526
            |:.....:..|..:.....|:..|.....:..:|.|||:..|:.||..|.|.:
  Rat   453 KEETKFAQVVLQDLDKKENGLRDILAVLTMKRDGSLQVTCTDQETGKCEAITV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	143/376 (38%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	177/508 (35%)
Hspa14	NP_001004257.1	HSPA14-like_NBD	2..376	CDD:212680	143/376 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810