DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-3 and HSPA12A

DIOPT Version :9

Sequence 1:NP_001285139.1 Gene:Hsc70-3 / 32133 FlyBaseID:FBgn0001218 Length:656 Species:Drosophila melanogaster
Sequence 2:NP_001317093.1 Gene:HSPA12A / 259217 HGNCID:19022 Length:692 Species:Homo sapiens


Alignment Length:672 Identity:158/672 - (23%)
Similarity:242/672 - (36%) Gaps:235/672 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 VIGIDLGTTYS-----------CVGVYKNGRVEIIANDQG--NRITPSYVAFTADGE-RLIGDAA 81
            |:.:|.|||.|           |:.|.:...    ..|.|  |:.||:.:..|.:.: ...|.||
Human    75 VVAVDFGTTSSGYAYSFTKEPECIHVMRRWE----GGDPGVSNQKTPTTILLTPERKFHSFGYAA 135

  Fly    82 K---NQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDT----SQGAKV 139
            :   :.|..|      :||:.:..|             .|| ::.::...:::||    :.|.||
Human   136 RDFYHDLDPN------EAKQWLYLE-------------KFK-MKLHTTGDLTMDTDLTAANGKKV 180

  Fly   140 FAPEEISAMVLGKMKETAEAYL----GKKVTHA----VVTVPAYFNDAQRQATKDAGVIAGL--- 193
            .| .||.|..|...||.|...|    |.:..::    |:||||.:....:|..:.|...|||   
Human   181 KA-LEIFAYALQYFKEQALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQAGLASP 244

  Fly   194 ---QVMRIINEPTAAAI--------------------AY-GLDK--------------------- 213
               :.:.|..||.||:|                    .| |.|.                     
Human   245 ENSEQLIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGFTQAKEHIRRNRQSRTF 309

  Fly   214 -------------KEGEKNVLVFDLGGGTFDVSL--LTIDNGVFEVV--ATNGDTHLGGEDFDQR 261
                         :||:|.|:| |.||||.|:::  :.:..|..:.:  ||.|.....|.|::  
Human   310 LVENVIGEIWSELEEGDKYVVV-DSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYE-- 371

  Fly   262 VMDHFIKLYKKKKGKDIRKDNRAVQKLRREV---------EKAKRALSGSHQVRIEIE---SF-- 312
                |.||..|..|:|..:.    .|::|..         |..|||.:......:.|.   ||  
Human   372 ----FEKLLYKIFGEDFIEQ----FKIKRPAAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFID 428

  Fly   313 ----FEGD-----------DF----SETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHE 358
                |.|.           ||    |:.:.|...:.:|. ||:.|:..:.:.|.|. ..|.:|..
Human   429 YYKKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNA-LFKPTIDSIIEHLRDL-FQKPEVST 491

  Fly   359 I---VLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAG-VLSGEQDTDAIVLLDV 419
            :   .||||....|.:||.|:..||  :..|.|.|.:.   |..:..| ||.|..  .|::.:..
Human   492 VKFLFLVGGFAEAPLLQQAVQAAFG--DQCRIIIPQDV---GLTILKGAVLFGLD--PAVIKVRR 549

  Fly   420 NPLTMGIETVGGVMTKLI-----PRNTVIP-------------------------TKKSQVFSTA 454
            :|||.|:    ||:.:.:     |...::.                         .|:|  ::.|
Human   550 SPLTYGV----GVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRS--YTPA 608

  Fly   455 SDNQHTVTIQVYEGER--------PMTKDNHLLGKFDLTGIP----PAPRGIPQIEVSF---EID 504
            ..:|..:.|.:|..|.        |..|....| :.||||..    ||.|.| |..:.|   ||.
Human   609 KPSQLVIVINIYSSEHDNVSFITDPGVKKCGTL-RLDLTGTSGTAVPARREI-QTLMQFGDTEIK 671

  Fly   505 ANGILQVSAEDKGTGNKEKIVI 526
            |..|      |..|....|:.|
Human   672 ATAI------DIATSKSVKVGI 687

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-3NP_001285139.1 HSPA5-like_NBD 29..403 CDD:212681 118/501 (24%)
PTZ00009 32..643 CDD:240227 157/671 (23%)
HSPA12ANP_001317093.1 HSPA12A_like_NBD 74..540 CDD:212685 121/507 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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