DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-3 and Hspa5

DIOPT Version :9

Sequence 1:NP_001285139.1 Gene:Hsc70-3 / 32133 FlyBaseID:FBgn0001218 Length:656 Species:Drosophila melanogaster
Sequence 2:NP_037215.1 Gene:Hspa5 / 25617 RGDID:2843 Length:654 Species:Rattus norvegicus


Alignment Length:657 Identity:529/657 - (80%)
Similarity:595/657 - (90%) Gaps:4/657 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKLCILLAVVAFVGLSLGEEKKEKDKELGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPS 65
            ||..::.|.:..: .::..|:::|.:::|||:|||||||||||||:|||||||||||||||||||
  Rat     1 MKFTVVAAALLLL-CAVRAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPS 64

  Fly    66 YVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHIS 130
            |||||.:||||||||||||||:|||||||||||||||.|:|.:||.||||.|||||||.:||:|.
  Rat    65 YVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQ 129

  Fly   131 VDTSQG-AKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQ 194
            ||...| .|.|||||||||||.|||||||||||||||||||||||||||||||||||||.||||.
  Rat   130 VDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLN 194

  Fly   195 VMRIINEPTAAAIAYGLDKKEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFD 259
            |||||||||||||||||||:|||||:|||||||||||||||||||||||||||||||||||||||
  Rat   195 VMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFD 259

  Fly   260 QRVMDHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTR 324
            ||||:|||||||||.|||:||||||||||||||||||||||..||.||||||||||:||||||||
  Rat   260 QRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFFEGEDFSETLTR 324

  Fly   325 AKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGIN 389
            |||||||:||||||:|||||||||:|:.|.|:.|||||||||||||:|||||:||.|||||||||
  Rat   325 AKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGIN 389

  Fly   390 PDEAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTA 454
            ||||||||||||||||||:|||..:|||||.|||:||||||||||||||||||:||||||:||||
  Rat   390 PDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTA 454

  Fly   455 SDNQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTG 519
            ||||.||||:|||||||:||||||||.||||||||||||:|||||:||||.||||:|:|||||||
  Rat   455 SDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTG 519

  Fly   520 NKEKIVITNDQNRLTPEDIDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGA 584
            ||.||.|||||||||||:|:||:.||||||:||||||||:::||||||||||||||||||:|||.
  Rat   520 NKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGG 584

  Fly   585 KLSDDEKNKLESAIDESIKWLEQNPDADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAPPPEGGDD 649
            |||.::|..:|.|::|.|:|||.:.|||.|::|.:||:||.||||:|:||| |:|| |||.|.:|
  Rat   585 KLSPEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLY-GSGG-PPPTGEED 647

  Fly   650 ADLKDEL 656
            ...||||
  Rat   648 TSEKDEL 654

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-3NP_001285139.1 HSPA5-like_NBD 29..403 CDD:212681 330/374 (88%)
PTZ00009 32..643 CDD:240227 512/611 (84%)
Hspa5NP_037215.1 Required for interaction with KIAA1324. /evidence=ECO:0000250|UniProtKB:P11021 1..80 52/79 (66%)
HSPA5-like_NBD 28..403 CDD:212681 330/374 (88%)
HSP70 30..635 CDD:278441 508/604 (84%)
Nucleotide-binding (NBD). /evidence=ECO:0000250|UniProtKB:P11021 125..280 138/154 (90%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 6/9 (67%)
Substrate-binding (SBD). /evidence=ECO:0000250|UniProtKB:P11021 420..500 70/79 (89%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..654 14/24 (58%)
Prevents secretion from ER 651..654 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166341329
Domainoid 1 1.000 1007 1.000 Domainoid score I25
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3908
Inparanoid 1 1.050 1059 1.000 Inparanoid score I238
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D237853at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 1 1.000 - - oto95510
orthoMCL 1 0.900 - - OOG6_100083
Panther 1 1.100 - - LDO PTHR19375
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2187
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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