DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and ssa1

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_593704.1	Gene:	ssa1 / 2542875	PomBaseID:	SPAC13G7.02c	Length:	644	Species:	Schizosaccharomyces pombe

Alignment Length:	645	Identity:	399/645 - (61%)
Similarity:	500/645 - (77%)	Gaps:	26/645 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVFDA 96
            |||||||||||||.:.|.||||||||||||.|||||||| |.|||||||||||:..||.||:|||
pombe     5 IGIDLGTTYSCVGHFSNNRVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPHNTIFDA 68

  Fly    97 KRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYL 161
            ||||||.::|..||.|:|.:||||:||:.||.|.|:.....|.|.|||||:|||.||:|:|||:|
pombe    69 KRLIGRRFNDPEVQSDMKHWPFKVIEKDGKPLIQVEFKGETKTFTPEEISSMVLLKMRESAEAFL 133

  Fly   162 GKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDK-KEGEKNVLVFDL 225
            |.|||.|||||||||||:|||||||||:||||.|:||||||||||||||||: .:.|.|||:|||
pombe   134 GGKVTDAVVTVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDRSNQHETNVLIFDL 198

  Fly   226 GGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRR 290
            ||||||||||||:.|:|||.||.|||||||||||.|:::||.:.:|:|..|||..:.|||::||.
pombe   199 GGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDSRLVNHFAQEFKRKNKKDITGNARAVRRLRT 263

  Fly   291 EVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKD 355
            ..|:|||.||.|.|..|||:|.:||.||..::|||:||||..||||:|::||:|||.|:.::|..
pombe   264 ACERAKRTLSSSAQASIEIDSLYEGIDFYTSITRARFEELCADLFRNTMEPVEKVLRDSKIDKSS 328

  Fly   356 VHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIVLLD 418
            |:||||||||||||::|:||.|||.||||.:.|||||||||||||||.:|.|:  :.|..::|||
pombe   329 VNEIVLVGGSTRIPRIQKLVSDFFNGKEPCKSINPDEAVAYGAAVQAAILVGDTSEKTQDLLLLD 393

  Fly   419 VNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFD 483
            |.||::||||.|||||.||.|||.||||||:||||.:|||..|.|||:||||..|||.:|||||:
pombe   394 VAPLSLGIETAGGVMTPLIKRNTTIPTKKSEVFSTYADNQPGVLIQVFEGERARTKDCNLLGKFE 458

  Fly   484 LTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDAEKF 548
            |:||||||||:|||||:|::||||||.|||.:||||..:||.||||:.||:.|:||||:.:|||:
pombe   459 LSGIPPAPRGVPQIEVTFDVDANGILNVSALEKGTGKTQKITITNDKGRLSKEEIDRMVSEAEKY 523

  Fly   549 ADEDKKLKERVESRNELESYAYSLKNQIGD---KDKLGAKLSDDEKNKLESAIDESIKWLEQNPD 610
            ..||:....|::::|.||||||||:|.:.|   |||:.|    .:|..::.|:.|:|:||:.|..
pombe   524 KAEDEAETSRIQAKNHLESYAYSLRNSLDDPNLKDKVDA----SDKEAIDKAVKETIEWLDHNTT 584

  Fly   611 ADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAP--------------PPEGGDDADLKDEL 656
            |..:||:.::|:||.:..|::||:|| |||||              .|.|.|:....:|:
pombe   585 AAKDEYEDKQKELEGVANPIMAKIYQ-AGGAPGGAPGGMPGGAPGGAPGGADNGPEVEEV 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	257/371 (69%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	395/630 (63%)
ssa1	NP_593704.1	PTZ00009	4..644	CDD:240227	399/645 (62%)
ssa1	NP_593704.1	HSPA1-2_6-8-like_NBD	4..378	CDD:212675	258/373 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720