DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and SPAC57A7.12

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_593369.1	Gene:	SPAC57A7.12 / 2542131	PomBaseID:	SPAC57A7.12	Length:	566	Species:	Schizosaccharomyces pombe

Alignment Length:	572	Identity:	164/572 - (28%)
Similarity:	270/572 - (47%)	Gaps:	112/572 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KELGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPE 90
            :|..|||||..|...|.:...::|:.:::||::|||..||.:::..|.| ..|..|:.||..|.:
pombe    21 EEYKTVIGISFGNQNSSIAFNRDGKTDVLANEEGNRQIPSILSYHGDQE-YHGVQARGQLVRNAD 84

  Fly    91 NTVFDAKRLIGREWSD------------TNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPE 143
            |:|.:.:.|:|:...:            .||:..|   .||:..:..:     ::....|:....
pombe    85 NSVTNFRDLLGKSHDELTLHHCHYSANPVNVEGQI---GFKITVQEDE-----ESDPKEKILTAH 141

  Fly   144 EISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIA 208
            |.|...|.::.|:||.:||.||...|::||.||.||||:|.:.|...|||.|:::|::|.|..:|
pombe   142 EASVRHLRRLTESAEDFLGTKVNGCVMSVPVYFTDAQRKALESAANEAGLPVLQLIHDPAAVILA 206

  Fly   209 YGLDKKE-GEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKK 272
            ....::. .:|.|:|.:.|....:||::::..|:..::|:..|.:||||.....:::.|.|.::|
pombe   207 LMYSEEVLIDKTVVVANFGATRSEVSVVSVKGGLMTILASVHDENLGGEQLTDVLVNFFAKEFEK 271

  Fly   273 KKGKDIRKDNRAVQKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFE-----ELN- 331
            |.|.|.||:.|::.|||.:.|..||.||........::|..:|.||..::.|.:::     .||
pombe   272 KNGIDPRKNARSLAKLRAQCEITKRVLSNGTTASAAVDSLADGIDFHSSINRLRYDLAASATLNR 336

  Fly   332 -LDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRG-------- 387
             .||       |.:.:|.|:|...|:.|::|.||::..||:..|::..|..:...|.
pombe   337 MADL-------VTEAVEKANMEPFDISEVILAGGASNTPKLTSLMESIFPEQTIIRSSSSVTPLQ 394

  Fly   388 INPDEAVAYGAAVQAGVLSGEQD-------TDAIVLLDVNPLT--MGIE------TVGGVMTKLI 437
            ::|.|..|.|:.|||.:: |..|       |||.| :||..||  :||.      |:..:.|.|.
pombe   395 LDPSELTAIGSGVQASLI-GHFDAADIAASTDAQV-VDVPHLTAPIGINEGENFVTIFDIETALP 457

  Fly   438 PRNT--VIPTKKSQVFSTASDNQHTVTIQVYEGER----------PMTKD--------------- 475
            .|.|  ||..|:...|           |.:||.||          |:.::
pombe   458 ARKTVEVIAPKEGAAF-----------IPIYEAERSVKVTKVEPEPIDEEEAFSDDEEEEPEEIK 511

  Fly   476 ------NHLLGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSA---EDKGT 518
                  ..|:....|..:.|..:    ||:..:|||.|.|..||   :.|||
pombe   512 ERIAIPKTLIATITLPDVSPNAK----IELVLQIDAEGKLTASARPKDGKGT 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	120/401 (30%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	161/566 (28%)
SPAC57A7.12	NP_593369.1	DnaK	22..554	CDD:223520	161/564 (29%)
SPAC57A7.12	NP_593369.1	ScSsz1p_like_NBD	25..410	CDD:212674	120/400 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900