DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and sks2

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_595438.1	Gene:	sks2 / 2540199	PomBaseID:	SPBC1709.05	Length:	613	Species:	Schizosaccharomyces pombe

Alignment Length:	607	Identity:	333/607 - (54%)
Similarity:	433/607 - (71%)	Gaps:	7/607 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVFDA 96
            ||||||||||||.|::...||||.||||.|.|||:|||| :.|||:|||||||...||.||||||
pombe     9 IGIDLGTTYSCVAVWETANVEIIPNDQGARTTPSFVAFT-ETERLVGDAAKNQAAMNPRNTVFDA 72

  Fly    97 KRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYL 161
            ||||||.:.|...|.|||.:||||::.|..|.|.|:.....|.|..:|||||||.||||.:||.|
pombe    73 KRLIGRRYEDPETQKDIKHWPFKVIDNNGIPTIEVNYLGEKKQFTAQEISAMVLTKMKEISEAKL 137

  Fly   162 GKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLD-KKEGEKNVLVFDL 225
            .|:|..||:||||||:|:||.||||||.||||.|:|||||||||||||||| |.:..||||:|||
pombe   138 NKRVEKAVITVPAYFSDSQRAATKDAGAIAGLNVLRIINEPTAAAIAYGLDAKSDKPKNVLIFDL 202

  Fly   226 GGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRR 290
            ||||||||||.|..|||||:||.|||||||||||..:::|||:.:|:|:..||..|.||:::||.
pombe   203 GGGTFDVSLLKIQGGVFEVLATAGDTHLGGEDFDNALVEHFIQEFKRKQKIDISDDPRALRRLRS 267

  Fly   291 EVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKD 355
            ..|:||||||...|..:|::|...|.|||.::|||:||::|...|::|:.||.|||:|:.:.|.|
pombe   268 ACERAKRALSSVTQTTVEVDSLSNGIDFSSSITRARFEDINATTFKATIDPVAKVLKDSKVPKAD 332

  Fly   356 VHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDTDA---IVLL 417
            ||:||||||||||||||:||.|||.|:..::.|||||||||||||||.||:.:.|:|.   ::||
pombe   333 VHDIVLVGGSTRIPKVQRLVSDFFDGRALNKSINPDEAVAYGAAVQAAVLTNKADSDKTQDLLLL 397

  Fly   418 DVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKF 482
            ||.||::|:...|.|...:.||||.|||.|.:.|:|.:|||.|||..||:|||....:|..||:|
pombe   398 DVVPLSLGVAMEGNVFGVVCPRNTPIPTIKKRTFTTVADNQTTVTFPVYQGERVNCAENEPLGEF 462

  Fly   483 DLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDAEK 547
            .||||||.|||..::|.:||:||||||:|:|.:|.||....|.|||....|:...|..||.:|:|
pombe   463 QLTGIPPMPRGQAELEATFELDANGILKVTAVEKTTGRSAHIEITNSVGHLSSTKIQEMIENADK 527

  Fly   548 FADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDAD 612
            |..:||...:::|::::||||..:::..|.:.:.: .||...:|:|:|:.:.|.:..||.. |.:
pombe   528 FKQQDKDFAKKLEAKSQLESYISNIETTISEPNVM-MKLKRGDKSKIEAQLAECMSQLELE-DTN 590

  Fly   613 PEEYKKQKKDLEAIVQPVIAKL 634
            .:..:|.:..|:..||...|.|
pombe   591 TDALRKAELRLKRTVQKAFASL 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	237/371 (64%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	333/607 (55%)
sks2	NP_595438.1	HSP70	8..613	CDD:278441	333/607 (55%)
		HSPA1-2_6-8-like_NBD	8..383	CDD:212675	239/374 (64%)
		BAR	<503..>603	CDD:299863	30/101 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710