Protein Alignment Hsc70-3 and Hspa1l

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_997711.1
• Gene: Hspa1l / 24963
• RGDID: 1595925
• Length: 641
• Species: Rattus norvegicus
• Alignment Length: 617
• Identity: 382/617 - (61%)
• Similarity: 492/617 - (79%)
• Gaps: 5/617 - (0%)

  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93
            |..||||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||:|||
  Rat     6 GMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPQNTV 69

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            |||||||||:::|..||.|:|.:||:|:.:..||.:.|......|.|.|||||:|||.|||||||
  Rat    70 FDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGKPKVLVSYKGEKKAFYPEEISSMVLTKMKETAE 134

  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDK-KEGEKNVLV 222
            |:||..||:||:||||||||:||||||||||||||.|:||||||||||||||||| ..||::||:
  Rat   135 AFLGHSVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVLI 199

  Fly   223 FDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQK 287
            |||||||||||:||||:|:|||.||.|||||||||||.|::.||::.:|:|..|||.::.|||::
  Rat   200 FDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRR 264

  Fly   288 LRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMN 352
            ||...|:|||.||.|.|..:||:|.:||.||..::|||:||||..||||.||:||:|.|.||.|:
  Rat   265 LRTACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKMD 329

  Fly   353 KKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIV 415
            |..:|:||||||||||||||:|::|:|.|::.::.|||||||||||||||.:|.|:  :....::
  Rat   330 KAKIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLL 394

  Fly   416 LLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLG 480
            ||||.||::|:||.|||||.||.||:.||||::|:|:|.||||..|.||||||||.||:||:|||
  Rat   395 LLDVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLLG 459

  Fly   481 KFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDA 545
            :||||||||||||:|||||:|:|||||||.|:|.||.||...||.||||:.||:.|:|:||:::|
  Rat   460 RFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSKEEIERMVQEA 524

  Fly   546 EKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPD 610
            |::..||:..:|::.::|.|||||:::|:.:|| :.|..|:|:.:|.|:.....|.:.|||.|..
  Rat   525 ERYKAEDEGQREKIAAKNALESYAFNMKSAVGD-EGLKDKISESDKKKILDKCSEVLSWLEANQL 588

  Fly   611 ADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAP 642
            |:.||:..::|:||.:..|:|.||||.....|
  Rat   589 AEKEEFDHKRKELENMCNPIITKLYQSGCTGP 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	381/614 (62%)
Hspa1l	NP_997711.1	PTZ00009	3..641	CDD:240227	382/617 (62%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		257/382 (67%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		81/114 (71%)