Protein Alignment Hsc70-3 and Hspa1a

DIOPT Version :9

• Sequence 1: NP_001285139.1
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_114177.2
• Gene: Hspa1a / 24472
• RGDID: 1593284
• Length: 641
• Species: Rattus norvegicus
• Alignment Length: 628
• Identity: 386/628 - (61%)
• Similarity: 498/628 - (79%)
• Gaps: 12/628 - (1%)

  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            |.||||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||:||||
  Rat     5 TAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVALNPQNTVF 68

  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEA 159
            ||||||||::.|..||.|:|.:||:||....||.:.|:.....:.|.|||||:|||.||||.|||
  Rat    69 DAKRLIGRKFGDPVVQSDMKHWPFQVVNDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKEIAEA 133

  Fly   160 YLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK-EGEKNVLVF 223
            |||..||:||:||||||||:||||||||||||||.|:||||||||||||||||:. :||:|||:|
  Rat   134 YLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIF 198

  Fly   224 DLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKL 288
            ||||||||||:||||:|:|||.||.|||||||||||.|::.||::.:|:|..|||.::.|||::|
  Rat   199 DLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRL 263

  Fly   289 RREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNK 353
            |...|:|||.||.|.|..:||:|.|||.||..::|||:||||..||||.||:||:|.|.||.::|
  Rat   264 RTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKLDK 328

  Fly   354 KDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIVL 416
            ..:|::|||||||||||||:|::|||.|::.::.|||||||||||||||.:|.|:  ::...::|
  Rat   329 AQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLL 393

  Fly   417 LDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGK 481
            |||.||::|:||.|||||.||.||:.||||::|.|:|.||||..|.||||||||.||:||:|||:
  Rat   394 LDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGR 458

  Fly   482 FDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDAE 546
            |:|:||||||||:|||||:|:|||||||.|:|.||.||...||.||||:.||:.|:|:||:::||
  Rat   459 FELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAE 523

  Fly   547 KFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDA 611
            ::..||:..:|||.::|.|||||:::|:.:.| :.|..|:|:.:|.|:.....|.|.||:.|..|
  Rat   524 RYKAEDEVQRERVAAKNALESYAFNMKSAVED-EGLKGKISEADKKKVLDKCQEVISWLDSNTLA 587

  Fly   612 DPEEYKKQKKDLEAIVQPVIAKLYQGAG-------GAPPPEGG 647
            :.||:..::::||.:..|:|:.||||||       ||..|:||
  Rat   588 EKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGAQAPKGG 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	254/373 (68%)
		PTZ00009	32..643	CDD:240227	382/620 (62%)
Hspa1a	NP_114177.2	PTZ00009	1..641	CDD:240227	386/628 (61%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		257/381 (67%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	254/375 (68%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		79/114 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..641		5/13 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830