DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and Hspa8

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_077327.1	Gene:	Hspa8 / 24468	RGDID:	621725	Length:	646	Species:	Rattus norvegicus

Alignment Length:	634	Identity:	402/634 - (63%)
Similarity:	501/634 - (79%)	Gaps:	17/634 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93
            |..:|||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||.|||
  Rat     4 GPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNTV 67

  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            |||||||||.:.|..||.|:|.:||.||....:|.:.|:.....|.|.|||:|:|||.||||.||
  Rat    68 FDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAE 132

  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKKEG-EKNVLV 222
            |||||.||:|||||||||||:|||||||||.||||.|:||||||||||||||||||.| |:|||:
  Rat   133 AYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLI 197

  Fly   223 FDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQK 287
            |||||||||||:|||::|:|||.:|.|||||||||||.|:::|||..:|:|..|||.::.|||::
  Rat   198 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRR 262

  Fly   288 LRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMN 352
            ||...|:|||.||.|.|..|||:|.:||.||..::|||:|||||.||||.||.||:|.|.||.::
  Rat   263 LRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLD 327

  Fly   353 KKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIV 415
            |..:|:||||||||||||:|:|::|||.|||.::.|||||||||||||||.:|||:  ::...::
  Rat   328 KSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLL 392

  Fly   416 LLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLG 480
            ||||.||::||||.|||||.||.|||.||||::|.|:|.||||..|.||||||||.|||||:|||
  Rat   393 LLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLG 457

  Fly   481 KFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDA 545
            ||:||||||||||:|||||:|:|||||||.|||.||.||.:.||.||||:.||:.|||:||:::|
  Rat   458 KFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEA 522

  Fly   546 EKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPD 610
            ||:..||:|.:::|.|:|.|||||:::|..:.| :||..|::|::|.|:....:|.|.||::|..
  Rat   523 EKYKAEDEKQRDKVSSKNSLESYAFNMKATVED-EKLQGKINDEDKQKILDKCNEIISWLDKNQT 586

  Fly   611 ADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAP------------PPEGG 647
            |:.||::.|:|:||.:..|:|.||||.|||.|            ||.||
  Rat   587 AEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGG 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	257/374 (69%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	397/625 (64%)
Hspa8	NP_077327.1	PTZ00009	1..613	CDD:240227	393/610 (64%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		261/382 (68%)
		Interaction with BAG1. /evidence=ECO:0000250	186..377		123/190 (65%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		85/114 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..646		8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730