Protein Alignment Hsc70-3 and HSPA4L

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_001304310.1
• Gene: HSPA4L / 22824
• HGNCID: 17041
• Length: 870
• Species: Homo sapiens
• Alignment Length: 706
• Identity: 193/706 - (27%)
• Similarity: 347/706 - (49%)
• Gaps: 118/706 - (16%)

  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            :|:|||||.....:.|.::|.:|.|||:..:|.||:.::. ....|.||:|||:|:.||..||:.
Human    33 SVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISL-GSRTRAIGNAAKSQIVTNVRNTIH 96

  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158
            ..|:|.||.:.|..||.:....|:::.: .|....:.|...:..:.||.|:::.|:|.|:|||:|
Human    97 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 161

  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK------EGE 217
            ..|.|.|...|:::|::|.||:|::...|..:|||..:|::||.||.|:|||:.|:      |..
Human   162 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEKP 226

  Fly   218 KNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDN 282
            :||:..|:|...:.|.:...:.|..:|:||..|.:|||.:||:.::|:|...:|.|...::::::
Human   227 RNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENS 291

  Fly   283 RAVQKLRREVEKAKRALS-GSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVL 346
            ||:.:|.:|.||.|:.:| .:..:.:.||.|....|.|..:.||:||:|...|......|::.|:
Human   292 RALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVM 356

  Fly   347 EDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDT 411
            |.|::.::|:..|.:|||:||||.|::.:..|| .|:.|..:|.|||||.|.|:|..:||.....
Human   357 EQANLQREDISSIEIVGGATRIPAVKEQITKFF-LKDISTTLNADEAVARGCALQCAILSPAFKV 420

  Fly   412 DAIVLLDVNPLTM------GIETVGG---VMTK--LIPRNTVIPTKKSQVFSTAS--DNQHTVTI 463
            ....:.|:.|.::      ..|...|   |..|  ..|.:.||...|.:.|...:  .|.|.|.
Human   421 REFSITDLVPYSITLRWKTSFEDGSGECEVFCKNHPAPFSKVITFHKKEPFELEAFYTNLHEVP- 484

  Fly   464 QVYEGERPMTKDNHLLGKFDLTGIPPAPRG-IPQIEVSFEIDANGILQVSA-------------- 513
              |...|        :|.|.:..:.|...| ..:::|...::.:||..|::
Human   485 --YPDAR--------IGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHS 539

  Fly   514 ------------------------EDKG----------------TGNKEKIVITNDQNRLTP--- 535
                                    :::|                ||.|.|..:::.|:||..
Human   540 DAPMETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLK 604

  Fly   536 --------------------ED-IDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQIGD- 578
                                :| ::..|.:..|...:||..|||.:::|.:|.|.|..::::|.
Human   605 KGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTV 669

  Fly   579 KDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADPEE-YKKQKKDLEAIVQPVIAK 633
            .:|.   ::.::.:||.:.::::..||.::.:..|:: |..:.::|:...||:..|
Human   670 YEKF---ITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMK 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	192/704 (27%)
HSPA4L	NP_001304310.1	ASKHA_NBD_HSP70_HSPA4L	33..415	CDD:466844	135/383 (35%)