DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-3 and Hspa1a

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_034609.2	Gene:	Hspa1a / 193740	MGIID:	96244	Length:	641	Species:	Mus musculus

Alignment Length:	627	Identity:	387/627 - (61%)
Similarity:	498/627 - (79%)	Gaps:	12/627 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            |.||||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||:||||
Mouse     5 TAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVALNPQNTVF 68

  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEA 159
            ||||||||::.|..||.|:|.:||:||....||.:.|:....::.|.|||||:|||.||||.|||
Mouse    69 DAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEIAEA 133

  Fly   160 YLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK-EGEKNVLVF 223
            |||..||:||:||||||||:||||||||||||||.|:||||||||||||||||:. :||:|||:|
Mouse   134 YLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIF 198

  Fly   224 DLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKL 288
            ||||||||||:||||:|:|||.||.|||||||||||.|::.||::.:|:|..|||.::.|||::|
Mouse   199 DLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRL 263

  Fly   289 RREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNK 353
            |...|:|||.||.|.|..:||:|.|||.||..::|||:||||..||||.||:||:|.|.||.|:|
Mouse   264 RTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDK 328

  Fly   354 KDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIVL 416
            ..:|::|||||||||||||:|::|||.|::.::.|||||||||||||||.:|.|:  ::...::|
Mouse   329 AQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLL 393

  Fly   417 LDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGK 481
            |||.||::|:||.|||||.||.||:.||||::|.|:|.||||..|.||||||||.||:||:|||:
Mouse   394 LDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGR 458

  Fly   482 FDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDAE 546
            |:|:||||||||:|||||:|:|||||||.|:|.||.||...||.||||:.||:.|:|:||:::||
Mouse   459 FELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAE 523

  Fly   547 KFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDA 611
            ::..||:..::||.::|.|||||:::|:.:.| :.|..|||:.:|.|:.....|.|.||:.|..|
Mouse   524 RYKAEDEVQRDRVAAKNALESYAFNMKSAVED-EGLKGKLSEADKKKVLDKCQEVISWLDSNTLA 587

  Fly   612 DPEEYKKQKKDLEAIVQPVIAKLYQGAG-------GAPPPEG 646
            |.||:..::::||.:..|:|:.||||||       ||..|:|
Mouse   588 DKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPKG 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	255/373 (68%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	384/620 (62%)
Hspa1a	NP_034609.2	PTZ00009	1..641	CDD:240227	387/627 (62%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		258/381 (68%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	255/375 (68%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		79/114 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..641		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730