Protein Alignment Hsc70-3 and Hspa1a

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_034609.2
• Gene: Hspa1a / 193740
• MGIID: 96244
• Length: 641
• Species: Mus musculus
• Alignment Length: 627
• Identity: 387/627 - (61%)
• Similarity: 498/627 - (79%)
• Gaps: 12/627 - (1%)

  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94
            |.||||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||:||||
Mouse     5 TAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVALNPQNTVF 68

  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEA 159
            ||||||||::.|..||.|:|.:||:||....||.:.|:....::.|.|||||:|||.||||.|||
Mouse    69 DAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEIAEA 133

  Fly   160 YLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK-EGEKNVLVF 223
            |||..||:||:||||||||:||||||||||||||.|:||||||||||||||||:. :||:|||:|
Mouse   134 YLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIF 198

  Fly   224 DLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKL 288
            ||||||||||:||||:|:|||.||.|||||||||||.|::.||::.:|:|..|||.::.|||::|
Mouse   199 DLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRL 263

  Fly   289 RREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNK 353
            |...|:|||.||.|.|..:||:|.|||.||..::|||:||||..||||.||:||:|.|.||.|:|
Mouse   264 RTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDK 328

  Fly   354 KDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDAIVL 416
            ..:|::|||||||||||||:|::|||.|::.::.|||||||||||||||.:|.|:  ::...::|
Mouse   329 AQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLL 393

  Fly   417 LDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGK 481
            |||.||::|:||.|||||.||.||:.||||::|.|:|.||||..|.||||||||.||:||:|||:
Mouse   394 LDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGR 458

  Fly   482 FDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIRDAE 546
            |:|:||||||||:|||||:|:|||||||.|:|.||.||...||.||||:.||:.|:|:||:::||
Mouse   459 FELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAE 523

  Fly   547 KFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDA 611
            ::..||:..::||.::|.|||||:::|:.:.| :.|..|||:.:|.|:.....|.|.||:.|..|
Mouse   524 RYKAEDEVQRDRVAAKNALESYAFNMKSAVED-EGLKGKLSEADKKKVLDKCQEVISWLDSNTLA 587

  Fly   612 DPEEYKKQKKDLEAIVQPVIAKLYQGAG-------GAPPPEG 646
            |.||:..::::||.:..|:|:.||||||       ||..|:|
Mouse   588 DKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPKG 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	384/620 (62%)
Hspa1a	NP_034609.2	PTZ00009	1..641	CDD:240227	387/627 (62%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		258/381 (68%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		79/114 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..641		4/12 (33%)