Protein Alignment Hsc70-3 and Hyou1

DIOPT Version :10

• Sequence 1: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_620222.2
• Gene: Hyou1 / 192235
• RGDID: 621146
• Length: 998
• Species: Rattus norvegicus
• Alignment Length: 708
• Identity: 196/708 - (27%)
• Similarity: 323/708 - (45%)
• Gaps: 123/708 - (17%)

  Fly     3 LC-ILLAVVAFVGLSLGEEKKEKDKELGTVIGIDLGTTYSCVGVYKNG-RVEIIANDQGNRITPS 65
            || .|:||:....|:|.:..        .|:.:|||:....|.:.|.| .:||:.|.:..|.||.
  Rat    14 LCWALVAVLLADLLALSDTL--------AVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPV 70

  Fly    66 YVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNV--------QHDIKFFPFK-VV 121
            .|.. .:.||.:||:|......||:.|:...:.|:|::..:.:|        :|::...|.: .|
  Rat    71 TVTL-KENERFLGDSAAGMAIKNPKATLRYFQHLLGKQADNPHVALYRSRFPEHELNVDPQRQTV 134

  Fly   122 EKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKD 186
            .....|.:.         |:|||:..|||...:..||.:..:.:..||:||||:||.|:|:|...
  Rat   135 RFQISPQLQ---------FSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPAFFNQAERRAVLQ 190

  Fly   187 AGVIAGLQVMRIINEPTAAAIAYGL----DKKEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVAT 247
            |..:|||:|:::||:.||.|::||:    |.....:|::.:|:|.|:...:::|     ::.|.|
  Rat   191 AARMAGLKVLQLINDNTATALSYGVFRRKDINSTAQNIMFYDMGSGSTVCTIVT-----YQTVKT 250

  Fly   248 NG--------------DTHLGGEDFDQRVMDHFIKLY----KKKKGKDIRKDNRAVQKLRREVEK 294
            ..              |..|||.:.:.|:.:|..||:    |.:|.||:|::.||:.||.||..:
  Rat   251 KEAGTQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQRKGQKAKDVRENPRAMAKLLREANR 315

  Fly   295 AKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEI 359
            .|..||.:.....:||...:..||...:||.:||||..|||.....|||:.|:.|:|:...:.::
  Rat   316 LKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFDRVPGPVQQALQSAEMSLDQIEQV 380

  Fly   360 VLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLD--VNPL 422
            :||||:||:||||:::....|.:|..:.||.|||.|.||..||..||........|:.|  :.|:
  Rat   381 ILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVIYPI 445

  Fly   423 ----TMGIETVGGVMT------KLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPM--TKD 475
                |..:|...|:.:      .|..|....|.:|...|:..|   |.....:..|:...  .:|
  Rat   446 LVEFTREVEEEPGLRSLKHNKRVLFSRMGPYPQRKVITFNRYS---HDFNFHINYGDLGFLGPED 507

  Fly   476 NHLLGKFDLT-----GIPPAPRGIPQ-----IEVSFEIDANGILQV-------------SAEDKG 517
            ..:.|..:||     |:..:.:..|.     |:..|.:|.:|:|.:             |.|::.
  Rat   508 LRVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSPEEES 572

  Fly   518 T----GNKEKIVITNDQNRLTPEDIDRMIRDAEKFADEDKK--------LKERVESRNELESYA- 569
            |    ||....:.....:....|:....:::.|:...|..|        |||..|:..|..|..
  Rat   573 TLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPAEGSKDEPAEQGELKEEAEAPMEDTSQPP 637

  Fly   570 -------YSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADPEEYKKQK 620
                   .:.:.:..|:.:.|.|....:.|:...|..|.:      |.| |||.||||
  Rat   638 PSEPKGDAAREGETPDEKESGDKSEAQKPNEKGQAGPEGV------PPA-PEEEKKQK 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	188/678 (28%)
Hyou1	NP_620222.2	ASKHA_NBD_HSP70_HYOU1	34..424	CDD:466828	131/404 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	564..694		30/132 (23%)
		PHA03169	<586..>691	CDD:223003	25/110 (23%)
		2A1904	<592..>800	CDD:273344	25/104 (24%)
		Prevents secretion from ER. /evidence=ECO:0000255	995..998