DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-3 and Hyou1

DIOPT Version :9

Sequence 1:	NP_001285139.1	Gene:	Hsc70-3 / 32133	FlyBaseID:	FBgn0001218	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_001029200.1	Gene:	Hyou1 / 192235	RGDID:	621146	Length:	998	Species:	Rattus norvegicus

Alignment Length:	708	Identity:	196/708 - (27%)
Similarity:	323/708 - (45%)	Gaps:	123/708 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LC-ILLAVVAFVGLSLGEEKKEKDKELGTVIGIDLGTTYSCVGVYKNG-RVEIIANDQGNRITPS 65
            || .|:||:....|:|.:..        .|:.:|||:....|.:.|.| .:||:.|.:..|.||.
  Rat    14 LCWALVAVLLADLLALSDTL--------AVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPV 70

  Fly    66 YVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNV--------QHDIKFFPFK-VV 121
            .|.. .:.||.:||:|......||:.|:...:.|:|::..:.:|        :|::...|.: .|
  Rat    71 TVTL-KENERFLGDSAAGMAIKNPKATLRYFQHLLGKQADNPHVALYRSRFPEHELNVDPQRQTV 134

  Fly   122 EKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKD 186
            .....|.:.         |:|||:..|||...:..||.:..:.:..||:||||:||.|:|:|...
  Rat   135 RFQISPQLQ---------FSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPAFFNQAERRAVLQ 190

  Fly   187 AGVIAGLQVMRIINEPTAAAIAYGL----DKKEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVAT 247
            |..:|||:|:::||:.||.|::||:    |.....:|::.:|:|.|:...:::|     ::.|.|
  Rat   191 AARMAGLKVLQLINDNTATALSYGVFRRKDINSTAQNIMFYDMGSGSTVCTIVT-----YQTVKT 250

  Fly   248 NG--------------DTHLGGEDFDQRVMDHFIKLY----KKKKGKDIRKDNRAVQKLRREVEK 294
            ..              |..|||.:.:.|:.:|..||:    |.:|.||:|::.||:.||.||..:
  Rat   251 KEAGTQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQRKGQKAKDVRENPRAMAKLLREANR 315

  Fly   295 AKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEI 359
            .|..||.:.....:||...:..||...:||.:||||..|||.....|||:.|:.|:|:...:.::
  Rat   316 LKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFDRVPGPVQQALQSAEMSLDQIEQV 380

  Fly   360 VLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLD--VNPL 422
            :||||:||:||||:::....|.:|..:.||.|||.|.||..||..||........|:.|  :.|:
  Rat   381 ILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVIYPI 445

  Fly   423 ----TMGIETVGGVMT------KLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPM--TKD 475
                |..:|...|:.:      .|..|....|.:|...|:..|   |.....:..|:...  .:|
  Rat   446 LVEFTREVEEEPGLRSLKHNKRVLFSRMGPYPQRKVITFNRYS---HDFNFHINYGDLGFLGPED 507

  Fly   476 NHLLGKFDLT-----GIPPAPRGIPQ-----IEVSFEIDANGILQV-------------SAEDKG 517
            ..:.|..:||     |:..:.:..|.     |:..|.:|.:|:|.:             |.|::.
  Rat   508 LRVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSPEEES 572

  Fly   518 T----GNKEKIVITNDQNRLTPEDIDRMIRDAEKFADEDKK--------LKERVESRNELESYA- 569
            |    ||....:.....:....|:....:::.|:...|..|        |||..|:..|..|..
  Rat   573 TLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPAEGSKDEPAEQGELKEEAEAPMEDTSQPP 637

  Fly   570 -------YSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADPEEYKKQK 620
                   .:.:.:..|:.:.|.|....:.|:...|..|.:      |.| |||.||||
  Rat   638 PSEPKGDAAREGETPDEKESGDKSEAQKPNEKGQAGPEGV------PPA-PEEEKKQK 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	131/405 (32%)
Hsc70-3	NP_001285139.1	PTZ00009	32..643	CDD:240227	188/678 (28%)
Hyou1	NP_001029200.1	HSP70	35..700	CDD:278441	189/679 (28%)
		HYOU1-like_NBD	36..424	CDD:212672	130/402 (32%)
		RR_TM4-6	549..>706	CDD:283990	32/147 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..694		30/132 (23%)
		Prevents secretion from ER. /evidence=ECO:0000255	995..998
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900